Observational studyAge (Dordrecht, Netherlands)2014
Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus.
Observational study in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Immunosenescence and Allergy: Molecular and Cellular Links Between Inflammaging, Neuro-Immune Aging, and Response to Biologic Therapies.International journal of molecular sciences · 2026Review
- Repair and regeneration across the lifespan: an ontogenetic perspective.Frontiers in aging · 2026Review
- LatentBiomolecules · 2025Article
- CMV-specific clonal expansion of Th1, GZMKbioRxiv : the preprint server for biology · 2025Article
- Understanding Telomere Biology in Hematopoietic Cell Transplantation: A Dynamical Systems Perspective.Transplantation and cellular therapy · 2025Article
- Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8Immunity & ageing : I & A · 2022Article
- Immunotoxicity of nanomaterials in health and disease: Current challenges and emerging approaches for identifying immune modifiers in susceptible populations.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
- Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing.Ageing research reviews · 2022Review
- Generation, maintenance and tissue distribution of T cell responses to human cytomegalovirus in lytic and latent infection.Medical microbiology and immunology · 2019Review
- Impact of CMV upon immune aging: facts and fiction.Medical microbiology and immunology · 2019Review
- Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia.PLoS pathogens · 2019Article
- Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults.Biomarker research · 2019Article
- Inflammaging: a new immune-metabolic viewpoint for age-related diseases.Nature reviews. Endocrinology · 2018Review
- Article
- Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution.GeroScience · 2018Article
- Impact of Aging, Cytomegalovirus Infection, and Long-Term Treatment for Human Immunodeficiency Virus on CD8Frontiers in immunology · 2018Article
- Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence.Molecular and cellular endocrinology · 2017Review
- Known unknowns: how might the persistent herpesvirome shape immunity and aging?Current opinion in immunology · 2017Review
- Checkpoint Inhibitors for Non-Small Cell Lung Cancer Among Older Adults.Current oncology reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Alterations in the circulating CD8+ T cell pool, with a loss of naïve and accumulation of effector/effector memory cells, are pronounced in older adults. However, homeostatic forces that dictate such changes remain incompletely understood. This observational cross-sectional study explored the basis for variability of CD8+ T cell number and composition of its main subsets: naïve, central memory and effector memory T cells, in 131 cytomegalovirus (CMV) seropositive subjects aged over 60 years. We found great heterogeneity of CD8+ T cell numbers, which was mainly due to variability of the CD8 + CD28- T cell subset regardless of age. Analysis, by multiple regression, of distinct factors revealed that age was a predictor for the loss in absolute number of naïve T cells, but was not associated with changes in central or effector memory CD8+ T cell subsets. By contrast, the size of CD8+ T cells specific to pp65 and IE-1 antigens of CMV, predicted CD28 - CD8+ T cell, antigen-experienced CD8+ T cell, and even total CD8+ T cell numbers, but not naïve CD8+ T cell loss. These results indicate a clear dichotomy between the homeostasis of naïve and antigen-experienced subsets of CD8+ T cells which are independently affected, in human later life, by age and antigen-specific responses to CMV, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.