ArticleFunctional & integrative genomics2014
Ruminal epithelium transcriptome dynamics in response to plane of nutrition and age in young Holstein calves.
Article in Functional & integrative genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Yeast culture in weaned lamb feed: a proteomic journey into enhanced rumen health and growth.Journal of animal science and biotechnology · 2025Article
- Proteomic identification of ruminal epithelial protein expression profiles in response to starter feed supplementation in pre-weaned lambs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Transcriptional Reprogramming in Rumen Epithelium during the Developmental Transition of Pre-Ruminant to the Ruminant in Cattle.Animals : an open access journal from MDPI · 2021Article
- Jersey steer ruminal papillae histology and nutrigenomics with diet changes.Journal of animal physiology and animal nutrition · 2019Article
- Regulation of rumen development in neonatal ruminants through microbial metagenomes and host transcriptomes.Genome biology · 2019Article
- Impact of weaning age on rumen development in artificially reared lambs1.Journal of animal science · 2019Article
- Metagenomic characterisation of ruminal bacterial diversity in buffaloes from birth to adulthood using 16S rRNA gene amplicon sequencing.Functional & integrative genomics · 2019Article
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- Nutrient supply alters transcriptome regulation in adipose tissue of pre-weaning Holstein calves.PloS one · 2018Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study assessed the effects of enhanced dietary plane of nutrition (early nutritional program (ENH)) on the gene expression pattern of ruminal epithelial tissue of young Holstein calves. Male Holstein calves were fed (3 to 42 days of age) with reconstituted control milk replacer (MR) (20 % crude protein, 20 % fat; 1.25 lb solids/calf) plus conventional starter (CON; 19.6 % crude protein, dry matter basis) or a high-protein MR (ENH; 28.5 % crude protein, 15 % fat; at around 2 % of body weight) plus high-crude protein starter (25.5 % crude protein, dry matter basis). The calves were weaned on day 43. Groups of calves in CON and ENH treatment were harvested after 5 and 10 weeks of feeding. The ruminal epithelium from five calves in each group was used for transcript profiling using a bovine oligonucleotide microarray. The postweaning mass of the reticulo-rumen was greater (P < 0.01) in calves consuming ENH. Transcriptome analysis revealed that 208 genes were altered due to treatment and 587 due to time alone. Bioinformatics analysis revealed that "galactose metabolism," "citrate cycle," "pyruvate metabolism," and "basal transcription factors" were the most impacted and induced pathways due to feeding ENH; whereas, "valine, leucine, and isoleucine biosynthesis" and "glyoxylate and dicarboxylate metabolism" were among the most inhibited. The integrated interpretation of the results suggested an overall increase in metabolism after weaning, particularly biosynthesis of glycan and nucleotide metabolism. Furthermore, the preweaning alterations in the transcriptome were mostly associated with cell growth, death, tissue development, and cellular morphology. The postweaning response revealed overexpression of genes associated with cell adhesion molecules, p53 signaling, and fatty acid metabolism. Our results indicated that feeding ENH to young Holstein calves elicited a strong transcriptomic response in the ruminal epithelial tissue.
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