ArticleGenome research2014
Evolution at two levels of gene expression in yeast.
Article in Genome research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed.
- Translation efficiency covariation identifies conserved coordination patterns across cell types.Nature biotechnology · 2026Article
- Discriminating models of trait evolution.Evolution; international journal of organic evolution · 2026Article
- Multi-Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Translational buffering tunes gene expression in mice and humans.Genome biology · 2026Article
- Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk.Nature communications · 2025Article
- The regulatory architecture of gene expression variation in Caenorhabditis elegans revealed by multi-strain allele-specific analysis.Genetics · 2025Article
- Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications.Genes · 2025Review
- The regulatory architecture of gene expression variation inbioRxiv : the preprint server for biology · 2025Article
- Article
- Quantifying Transcriptome Turnover on Phylogenies by Modeling Gene Expression as a Binary Trait.Molecular biology and evolution · 2025Article
- Macroevolutionary divergence of gene expression driven by selection on protein abundance.Science (New York, N.Y.) · 2025Article
- Translation variation across genetic backgrounds reveals a post-transcriptional buffering signature in yeast.Nucleic acids research · 2024Article
- On the Decoupling of Evolutionary Changes in mRNA and Protein Levels.Molecular biology and evolution · 2023Article
- Dynamic Spatial-temporal Expression Ratio of X Chromosome to Autosomes but Stable Dosage Compensation in Mammals.Genomics, proteomics & bioinformatics · 2023Article
- Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs.PLoS genetics · 2023Article
- Decoupling of evolutionary changes in mRNA and protein levels.bioRxiv : the preprint server for biology · 2023Article
- Ribosome profiling reveals the translational landscape and allele-specific translational efficiency in rice.Plant communications · 2023Article
- The landscape of transcriptional and translational changes over 22 years of bacterial adaptation.eLife · 2022Article
- Phenotypic mutations contribute to protein diversity and shape protein evolution.Protein science : a publication of the Protein Society · 2022Review
- Evolution of transcription factor binding through sequence variations and turnover of binding sites.Genome research · 2022Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Despite the greater functional importance of protein levels, our knowledge of gene expression evolution is based almost entirely on studies of mRNA levels. In contrast, our understanding of how translational regulation evolves has lagged far behind. Here we have applied ribosome profiling--which measures both global mRNA levels and their translation rates--to two species of Saccharomyces yeast and their interspecific hybrid in order to assess the relative contributions of changes in mRNA abundance and translation to regulatory evolution. We report that both cis- and trans-acting regulatory divergence in translation are abundant, affecting at least 35% of genes. The majority of translational divergence acts to buffer changes in mRNA abundance, suggesting a widespread role for stabilizing selection acting across regulatory levels. Nevertheless, we observe evidence of lineage-specific selection acting on several yeast functional modules, including instances of reinforcing selection acting at both levels of regulation. Finally, we also uncover multiple instances of stop-codon readthrough that are conserved between species. Our analysis reveals the underappreciated complexity of post-transcriptional regulatory divergence and indicates that partitioning the search for the locus of selection into the binary categories of "coding" versus "regulatory" may overlook a significant source of selection, acting at multiple regulatory levels along the path from genotype to phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.