ArticleRheumatology international2014
Do patients with juvenile idiopathic arthritis in remission exhibit active synovitis on joint ultrasound?
Article in Rheumatology international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- From Hands to Imaging: The Emerging Role of Musculoskeletal Ultrasonography in Juvenile Idiopathic Arthritis Disease Activity Assessment.International journal of rheumatic diseases · 2026Article
- Application of a novel Musculoskeletal Ultrasound Sum Score (MUSS) in the follow-up of patients with juvenile idiopathic arthritis.Rheumatology (Oxford, England) · 2026Article
- Hip Joint Synovial Cavity Thickness in Early Juvenile Idiopathic Arthritis Without Effusion: A Cross-Sectional Ultrasound Study.Journal of clinical medicine · 2026Article
- Knee-ultrasound: reference values for the amount of joint fluid and synovial appearances in healthy children and adolescents.Pediatric radiology · 2025Article
- A clinical perspective on imaging in juvenile idiopathic arthritis.Pediatric radiology · 2024Review
- The importance of ultrasound examination in care of juvenile idiopathic arthritis patients: 9 months follow-up study.Frontiers in pediatrics · 2024Article
- Ultrasonographic evaluation of changes in the joint before and after intra-articular injection in children with juvenile idiopathic arthritis.Northern clinics of Istanbul · 2024Article
- Ultrasound in pediatric rheumatology: Highlighting the differences with adults.European journal of rheumatology · 2022Article
- Foot and Ankle Conventional Radiography in Juvenile Idiopathic Arthritis: Does It Still Matter?Journal of the Belgian Society of Radiology · 2022Article
- Serum Calprotectin a Potential Biomarker in Juvenile Idiopathic Arthritis: A Meta-Analysis.Journal of clinical medicine · 2021Review
- Musculoskeletal ultrasound in children: Current state and future directions.European journal of rheumatology · 2020Article
- Biomarkers of Response to Biologic Therapy in Juvenile Idiopathic Arthritis.Frontiers in pharmacology · 2020Review
- Evaluation of the thicknesses of cartilage and enthesis in familial Mediterranean fever and enthesitis-related arthritis.Northern clinics of Istanbul · 2020Article
- Bilateral brachial synovial cysts in systemic juvenile idiopathic arthritis: Case report and literature review.International journal of rheumatic diseases · 2019Review
- Ultrasound assessment as predictor of disease relapse in children and adults with arthritis in clinical stable remission: new findings but still unmet needs.Annals of the rheumatic diseases · 2018Article
- Imaging of the hip in juvenile idiopathic arthritis.Pediatric radiology · 2018Review
- Patients with juvenile idiopathic arthritis in clinical remission with positive power Doppler signal in joint ultrasonography have an increased rate of clinical flare: a prospective study.Pediatric rheumatology online journal · 2017Article
- Juvenile idiopathic arthritis: what is the utility of ultrasound?The British journal of radiology · 2017Review
- Attitudes and Approaches for Withdrawing Drugs for Children with Clinically Inactive Nonsystemic JIA: A Survey of the Childhood Arthritis and Rheumatology Research Alliance.The Journal of rheumatology · 2017Article
- Establishing percentile charts for hip joint capsule and synovial cavity thickness in apparently healthy children.Pediatric rheumatology online journal · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to assess the presence and characteristics of subclinical synovitis using power Doppler (PD) ultrasonography on patients with juvenile idiopathic arthritis (JIA) in clinical remission and compare the findings with those of healthy children. A cross-sectional study was carried out involving the clinical (physical exam, functional capacity and laboratory tests) and ultrasonography evaluation of 34 joints (synovial fluid/hypertrophy, PD signal and bone erosion). Subclinical synovitis was defined as the presence of synovial hypertrophy/joint effusion with or without any PD signal. Thirty-six patients (11.5 ± 3.74 years) and 36 controls (sex and age matched) were evaluated (2,448 joints). Twenty-seven patients were in remission on medication (mean duration: 1.8 ± 2.2 years). Subclinical synovitis was detected in 41.7% patients and 11.1% controls (p = 0.003). Erosion was detected in three patients (8.3%). Subclinical synovitis was found in 38/1,224 (3.1%) joints in the patients (most affected: radiocarpal wrist, anterior elbow and tibiotalar ankle) and 8/1,224 (0.6%) joints in the controls (most affected: radiocarpal wrist). Differences in subclinical synovitis between patients and controls were found in the elbows (p = 0.033) and ankles (p = 0.006). A greater frequency of subclinical synovitis was found in patients with the extended oligoarticular or polyarticular subtypes (p = 0.013), those at an older age at disease onset (p = 0.007) and using methotrexate (p = 0.049). Patients with JIA in remission exhibit subclinical synovitis more frequently than controls. Subclinical synovitis was more frequent in patients with the polyarticular involvement and those at an older age at disease onset.
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