Evidence map›Paper›PMID 24318110›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2014

PEDF expression regulates the proangiogenic and proinflammatory phenotype of the lung endothelium.

Eui Seok Shin, Christine M Sorenson, Nader Sheibani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Tyrosine-Mutant AAV8 Vector Mediated Efficient and Safe Gene Transfer of Pigment Epithelium-Derived Factor to Mouse Lungs.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Eui Seok ShinDept. of Ophthalmology and Visual Sciences, Univ. of Wisconsin, 600 Highland Ave., K6/458 CSC, Madison, WI 53792-4673. nsheibanikar@wisc.edu.
Christine M Sorenson
Nader Sheibani
University of Wisconsin–Madison · USSmith-Kettlewell Eye Research Institute · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2005 to 2026
$12.6M
Novel Antiangiogenic Peptides for Treatment of Exudative AMDR24EY022883 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SHEIBANI, NADER · 2013 to 2017
$6.2M
Integrated Multidisciplinary Strategies for Detection of Diabetic RetinopathiesRC4EY021357 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ASSADI, AMIR H, ASSADI-PORTER, FARIBA M · 2010 to 2010
$3.2M
Bcl-2 and ocular neovascularizationR21EY023024 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SORENSON, CHRISTINE M · 2013 to 2014
$410k
NCI NIH HHS P30 CA-014520NCI NIH HHS P30 CA014520NEI NIH HHS P30 EY016665NEI NIH HHS P30EY-016665NEI NIH HHS R01 EY-016995NEI NIH HHS R21 EY-023024NEI NIH HHS R24 EY022883NEI NIH HHS RC4 EY-021357
6 · The paper itself

Abstract

Pigment epithelium-derived factor (PEDF) is a multifunctional protein with important roles in regulation of inflammation and angiogenesis. It is produced by various cell types, including endothelial cells (EC). However, the cell autonomous impact of PEDF on EC function needs further investigation. Lung EC prepared from PEDF-deficient (PEDF-/-) mice were more migratory and failed to undergo capillary morphogenesis in Matrigel compared with wild type (PEDF+/+) EC. Although no significant differences were observed in the rates of apoptosis in PEDF-/- EC compared with PEDF+/+ cells under basal or stress conditions, PEDF-/- EC proliferated at a slower rate. PEDF-/- EC also expressed increased levels of proinflammatory markers, including vascular endothelial growth factor, inducible nitric oxide synthase, vascular cell adhesion molecule-1, as well as altered cellular junctional organization, and nuclear localization of β-catenin. The PEDF-/- EC were also more adhesive, expressed decreased levels of thrombospondin-2, tenascin-C, and osteopontin, and increased fibronectin. Furthermore, we showed lungs from PEDF-/- mice exhibited increased expression of macrophage marker F4/80, along with increased thickness of the vascular walls, consistent with a proinflammatory phenotype. Together, our data suggest that the PEDF expression makes significant contribution to modulation of the inflammatory and angiogenic phenotype of the lung endothelium.

Indexed as

AnimalsAntigens, CDAntigens, DifferentiationApoptosisbeta CateninCadherin 5CadherinsCell AdhesionCell MovementCell ProliferationEndothelial CellsEye ProteinsLungMiceNeovascularization, PhysiologicNerve Growth FactorsAntigens, CDAntigens, Differentiationbeta CateninCadherin 5CadherinsCTNNB1 protein, mouseEye Proteinsmonocyte-macrophage differentiation antigenNerve Growth FactorsNitric Oxide Synthase Type IIPigment Epithelium-Derived FactorPlatelet Endothelial Cell Adhesion Molecule-1SerpinsVascular Endothelial Growth Factor Aadherens junctionsangiogenesisinflammationthrombospondinWnt signaling

Identifiers

PMID24318110
PMCPMC3962624
OpenAlexW2068997922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.