Trial reportJournal of assisted reproduction and genetics2014
A randomized controlled trial comparing two vitrification methods versus slow-freezing for cryopreservation of human cleavage stage embryos.
Trial report in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance.Human reproduction update · 2017Pooled it
- Effect of embryo morphology and morphometrics on implantation of vitrified day 3 embryos after warming: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2016Trial
- Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/082, May 2025).Geburtshilfe und Frauenheilkunde · 2026Article
- Maternal and Perinatal Outcomes in Women with Polycystic Ovary Syndrome Undergoing Artificial Frozen-Thawed Embryo Transfer Cycles: A Retrospective Study.Advanced biomedical research · 2025Article
- The Effect of Uterine Length Measurement before Embryo Transfer versus Transabdominal Ultrasound-Guided Embryo Transfer on FET Cycle Outcome: A Randomised Clinical Trial.International journal of fertility & sterility · 2024Article
- Vitrification of human blastocysts for couples undergoing assisted reproduction: an updated review.Frontiers in cell and developmental biology · 2024Review
- Comparative Assessment of Survival and Clinical Outcome Between Two Commercial Vitrification Kits with Different Warming Protocols After Blastocyst Culture: Potential Perspectives Toward Simplified Warming Procedures.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Effect of exposed-to-air frequency of cryopreserved embryo on clinical outcomes of vitrified-warmed embryo transfer cycles: a retrospective analysis of 9,200 vitrified-warmed transfer cycles.BMC pregnancy and childbirth · 2023Article
- An all-37 °C thawing method improves the clinical outcomes of vitrified frozen-thawed embryo transfer: a retrospective study using a case-control matching analysis.Archives of gynecology and obstetrics · 2023Article
- Automation in vitrification and thawing of mouse oocytes and embryos.Frontiers in cell and developmental biology · 2023Article
- Intensification of camel farming and milk production with special emphasis on animal health, welfare, and the biotechnology of reproduction.Animal frontiers : the review magazine of animal agriculture · 2022Article
- An Interplay between Epigenetics and Translation in Oocyte Maturation and Embryo Development: Assisted Reproduction Perspective.Biomedicines · 2022Review
- The effect of transferring a poor-quality embryo together with a good-quality embryo on the singleton birth weight: A retrospective cohort study.International journal of reproductive biomedicine · 2022Article
- A freeze-all strategy does not increase live birth rates in women of advanced reproductive age.Journal of assisted reproduction and genetics · 2020Article
- Dynamics of trophoblast differentiation in peri-implantation-stage human embryos.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A monocentric analysis of the efficacy of extracellular cryoprotectants in unfrozen solutions for cleavage stage embryos.Reproductive biology and endocrinology : RB&E · 2019Article
- A new, simple, automatic vitrification device: preliminary results with murine and bovine oocytes and embryos.Journal of assisted reproduction and genetics · 2018Article
- Outcomes of neonates born following transfers of frozen-thawed cleavage-stage embryos with blastomere loss: a prospective, multicenter, cohort study.BMC medicine · 2018Article
- Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, DGU and DGRM (S2k-Level, AWMF Registry No. 015/082, November 2017) - Recommendations and Statements for Girls and Women.Geburtshilfe und Frauenheilkunde · 2018Article
- Effect of day 3 embryo morphometrics and morphokinetics on survival and implantation after slow freezing-thawing and after vitrification-warming: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare two different vitrification methods to slow freezing method for cryopreservation of human cleavage stage embryos.
designProspective randomised trial.
settingUniversity assisted reproduction centre. PATIENT(S): 568 patients (mean age 33.4 ± 5.2) from April 2009 to April 2011.
methods1798 supernumerary good-quality cleavage stage embryos in 645 IVF cycles intended to be cryopreserved were randomly allocated to three groups: slow freezing, vitrification with the Irvine® method, vitrification with the Vitrolife® method. MAIN OUTCOME MEASURE(S): Embryo survival and cleavage rates, implantation rate.
resultsA total of 1055 embryos were warmed, 836 (79.2%) survived and 676 were finally transferred (64.1%). Post-warming embryos survival rate was significantly higher after vitrification (Irvine: 89.4%; Vitrolife: 87.6%) than after slow freezing (63.8%) (p < 0.001). No differences in survival rates were observed between the two vitrification methods, but a significant higher cleavage rate was observed using Irvine compared to Vitrolife method (p < 0.05). Implantation rate (IR) per embryo replaced and per embryo warmed were respectively 15.8% (41/259) and 12.4% (41/330) for Irvine, 17.0% (40/235) and 12.1% (40/330) for Vitrolife, 21.4% (39/182) and 9.9% (39/395) for slow-freezing (NS).
conclusionsBoth vitrification methods (Irvine and Vitrolife) are more efficient than slow freezing for cryopreservation of human cleavage stage embryos in terms of post-warming survival rate. No significant difference in the implantation rate was observed between the three cryopreservation methods.
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