ReviewBrain imaging and behavior2014
Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer's disease.
Review in Brain imaging and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Long-term Effects on Cognitive Trajectories of Postmenopausal Hormone Therapy in Two Age Groups.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Trial
- Effect of a Long-Term Intensive Lifestyle Intervention on Cognitive Function: Action for Health in Diabetes Study.Journal of the American Geriatrics Society · 2017Trial
- Brain and White Matter Hyperintensity Volumes After 10 Years of Random Assignment to Lifestyle Intervention.Diabetes care · 2016Trial
- Associations of white matter hyperintensity regression and progression with cognitive and structural brain changes: a population-based cohort study.Alzheimer's research & therapy · 2026Article
- Features of Mitochondrial Dynamics in Different Brain Parts of Patients with Alzheimer's Disease.International journal of molecular sciences · 2025Article
- Neurite Degradation Mediates the Effect of Amyloid Deposition on Global Cognition in Asymptomatic Older Adults.medRxiv : the preprint server for health sciences · 2025Article
- Dysfunction in the hierarchy of morphometric similarity network in Alzheimer's disease and its correlation with cognitive performance and gene expression profiles.Psychological medicine · 2025Article
- Functional network centrality indicates interactions between APOE4 and age across the clinical spectrum of Alzheimer's Disease.NeuroImage. Clinical · 2024Article
- A Novel Serum-Based Diagnosis of Alzheimer's Disease Using an Advanced Phage-Based Biochip.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Review
- Physical fitness, cognition, and structural network efficiency of brain connections across the lifespan.Neuropsychologia · 2023Article
- Alzheimer's Disease and Empathic Abilities: The Proposed Role of the Cingulate Cortex.Journal of Alzheimer's disease reports · 2021Review
- Translational and interdisciplinary insights into presbyacusis: A multidimensional disease.Hearing research · 2021Review
- Bridging Scales in Alzheimer's Disease: Biological Framework for Brain Simulation With The Virtual Brain.Frontiers in neuroinformatics · 2021Review
- An Integrative Approach to Study Structural and Functional Network Connectivity in Epilepsy Using Imaging and Signal Data.Frontiers in integrative neuroscience · 2020Article
- Effects of pioglitazone on mnemonic hippocampal function: A blood oxygen level-dependent functional magnetic resonance imaging study in elderly adults.Alzheimer's & dementia (New York, N. Y.) · 2019Article
- Computational modeling and biomarker studies of pharmacological treatment of Alzheimer's disease (Review).Molecular medicine reports · 2018Review
- Lower cognitive control network connectivity in stroke participants with depressive features.Translational psychiatry · 2018Article
- Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults.PloS one · 2018Article
- Cognitive Reserve and the Prevention of Dementia: the Role of Physical and Cognitive Activities.Current psychiatry reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Neuroimaging has rapidly advanced investigations into dysfunction both within and emanating from the hippocampus in early Alzheimer's disease . Focusing on prodromal subjects, we will discuss structural changes to hippocampal subregions, alterations to functional activity both within the hippocampus and elsewhere in the cortex, as well as changes to structural white matter connectivity and changes to functionally correlated patterns during memory performance. We present ample evidence that asymptomatic subjects demonstrate substantial identifiable brain changes before the onset of cognitive decline, but suggest there is significant work yet to be accomplished before applying these findings to individual patients.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.