ArticleNutrients2013
Salty taste acuity is affected by the joint action of αENaC A663T gene polymorphism and available zinc intake in young women.
Article in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- COVID-19 as a worldwide selective event and bitter taste receptor polymorphisms: An ecological correlational study.International journal of biological macromolecules · 2021Pooled it
- Pooled it
- Quantitive Assessment of Gustatory Function and Its Association with Demographics, and Systemic Morbidity.Biology · 2024Article
- Smell, taste and food habits changes along body mass index increase: an observational study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Observational
- Article
- The impact of excessive salt intake on human health.Nature reviews. Nephrology · 2022Review
- Impact of Nutritional Intervention on Taste Perception-A Scoping Review.Foods (Basel, Switzerland) · 2021Article
- Association of αENaC p. Ala663Thr Gene Polymorphism With Sudden Sensorineural Hearing Loss.Frontiers in genetics · 2021Article
- Elevated Salt Taste Threshold Is Associated with Increased Risk of Coronary Heart Disease.Journal of cardiovascular translational research · 2020Article
- Effect of Salt Reduction on Consumer Acceptance and Sensory Quality of Food.Foods (Basel, Switzerland) · 2017Review
- Arginyl dipeptides increase the frequency of NaCl-elicited responses via epithelial sodium channel alpha and delta subunits in cultured human fungiform taste papillae cells.Scientific reports · 2017Article
- Dietary Sodium Intake is Predicted by Antihypertensive Medication Regimen in Patients With Heart Failure.The Journal of cardiovascular nursingObservational
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salty taste perception affects salt intake, of which excess amounts is a major public health concern. Gene polymorphisms in salty taste receptors, zinc status and their interaction may affect salty taste perception. In this study, we examined the relationships among the α-epithelial sodium channel (αENaC) A663T genotype, zinc intake, and salty taste perception including salty taste acuity and preference in healthy young adults. The αENaC A663T genotype was determined by the PCR-restriction fragment length polymorphism in 207 adults. Zinc intake was examined by one 24-h recall and a two-day dietary record. Salty taste acuity and preference were determined by measuring the salty taste recognition threshold and the preferred salinity of beansprout soup, respectively. Men had significantly higher thresholds and preferences for salty taste than women did (p < 0.05). In women, the salty taste threshold was significantly lower in the highest tertile of available zinc intake than in the lowest tertile (12.2 mM and 17.6 mM, respectively, p = 0.02). Interestingly, a significant inverse association between available zinc intake and salty taste threshold was found only in women with αENaC AA homozygotes (β = -0.833, p = 0.02), and no such association was found in T663 allele carriers. The salty taste preference was not associated with the αENaC A663T genotype or available zinc intake in either sex. In conclusion, our data suggest that gene-nutrient interactions between the αENaC A663T genotype and available zinc intake play a role in determining the salty taste acuity in young women.
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