ArticleOncogene2014
p21Waf1/Cip1 deficiency causes multiple mitotic defects in tumor cells.
Article in Oncogene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 46 citations in OpenAlex.
- Dual role of p21 in regulating apoptosis and mitotic integrity in response to doxorubicin in colon cancer cells.Cell death discovery · 2025Article
- Twenty years of merotelic kinetochore attachments: a historical perspective.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Review
- Revisiting the Function of p21International journal of molecular sciences · 2022Review
- Nintedanib ameliorates oxidized low-density lipoprotein -induced inflammation and cellular senescence in vascular endothelial cells.Bioengineered · 2022Article
- Antiproliferative effects of dried Moringa oleifera leaf extract on human Wharton's Jelly mesenchymal stem cells.PloS one · 2022Article
- MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway.FEBS open bio · 2021Article
- Article
- Chromatin-Directed Proteomics Identifies ZNF84 as a p53-Independent Regulator of p21 in Genotoxic Stress Response.Cancers · 2021Article
- The p53/p73 - p21Oncogene · 2021Article
- Network mechanisms and dysfunction within an integrated computational model of progression through mitosis in the human cell cycle.PLoS computational biology · 2020Article
- Nuclear myosin 1 activates p21 gene transcription in response to DNA damage through a chromatin-based mechanism.Communications biology · 2020Article
- RITA modulates cell migration and invasion by affecting focal adhesion dynamics.Molecular oncology · 2019Article
- The Role of the Cyclin Dependent Kinase Inhibitor p21Cancers · 2019Review
- The Multifaceted p21 (Cip1/Waf1/Cancers · 2019Review
- Function of p21 (Cip1/Waf1/Cancers · 2019Article
- Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition.Molecular cancer research : MCR · 2019Article
- Potential involvement of RITA in the activation of Aurora A at spindle poles during mitosis.Oncogene · 2019Article
- MYCN is amplified during S phase, and c‑myb is involved in controlling MYCN expression and amplification in MYCN‑amplified neuroblastoma cell lines.Molecular medicine reports · 2019Article
- The Cell Cycle Inhibitors p21Neoplasia (New York, N.Y.) · 2017Article
- Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics.Oncogene · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a multifaceted molecule, p21 plays multiple critical roles in cell cycle regulation, differentiation, apoptosis, DNA repair, senescence, aging and stem cell reprogramming. The important roles of p21 in the interphase of the cell cycle have been intensively investigated. The function of p21 in mitosis has been proposed but not systematically studied. We show here that p21 is abundant in mitosis and binds to and inhibits the activity of Cdk1/cyclin B1. Deficiency of p21 prolongs the duration of mitosis by extending metaphase, anaphase and cytokinesis. The activity of Aurora B is reduced and the localization of Aurora B on the central spindle is disturbed in anaphase cells without p21. Moreover, HCT116 p21-/-, HeLa and Saos-2 cells depleted of p21 encounter problems in chromosome segregation and cytokinesis. Gently inhibiting the mitotic Cdk1 or add-back of p21 rescues segregation defect in HCT116 p21-/- cells. Our data demonstrate that p21 is important for a fine-tuned control of the Cdk1 activity in mitosis, and its proper function facilitates a smooth mitotic progression. Given that p21 is downregulated in the majority of tumors, either by the loss of tumor suppressors like p53 or by hyperactive oncogenes such as c-myc, this finding also sheds new light on the molecular mechanisms by which p21 functions as a tumor suppressor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.