ArticlePsychopharmacology2014
The effects of nicotine exposure during Pavlovian conditioning in rats on several measures of incentive motivation for a conditioned stimulus paired with water.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06259630 (Effect of Nicotine on Acquisition and Extinction of a Conditioned Place Preference in a Virtual Reality Environment), which is not on this map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Nicotine on Acquisition and Extinction of a Conditioned Place Preference in a Virtual Reality Environment
Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue.Frontiers in behavioral neuroscience · 2022Article
- Nicotine Enhances Goal-Tracking in Ethanol and Food Pavlovian Conditioned Approach Paradigms.Frontiers in neuroscience · 2021Article
- Nicotine Self-Administration With Tobacco Flavor Additives in Male Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Sex differences in nicotine-enhanced Pavlovian conditioned approach in rats.Biology of sex differences · 2019Article
- Nicotine-enhanced Pavlovian conditioned approach is resistant to omission of expected outcome.Behavioural brain research · 2018Article
- Orbitofrontal participation in sign- and goal-tracking conditioned responses: Effects of nicotine.Neuropharmacology · 2017Article
- Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats.Psychopharmacology · 2017Article
- Chronic Nicotine Exposure Initiated in Adolescence and Unpaired to Behavioral Context Fails to Enhance Sweetened Ethanol Seeking.Frontiers in behavioral neuroscience · 2017Article
- The tendency to sign-track predicts cue-induced reinstatement during nicotine self-administration, and is enhanced by nicotine but not ethanol.Psychopharmacology · 2016Article
- Nicotine administration enhances negative occasion setting in adolescent rats.Behavioural brain research · 2016Article
- Individual variation in the motivational properties of a nicotine cue: sign-trackers vs. goal-trackers.Psychopharmacology · 2015Article
- Quantifying nicotine's value-enhancement effect using a behavioral economic approach.Journal of the experimental analysis of behavior · 2014Article
- The form of a conditioned stimulus can influence the degree to which it acquires incentive motivational properties.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleNicotine enhances approach toward and operant responding for conditioned stimuli (CSs), but the effect of exposure during different phases of Pavlovian incentive learning on these measures remains to be determined.
objectivesThese studies examined the effects of administering nicotine early, late or throughout Pavlovian conditioning trials on discriminated approach behavior, nicotine-enhanced responding for conditioned reinforcement, extinction, and the reinstatement of responding for conditioned reinforcement. We also tested the effect of nicotine on approach to a lever-CS in a Pavlovian autoshaping procedure and for this CS to serve as a conditioned reinforcer.
methodsThirsty rats were exposed to 13 conditioning sessions where a light/tone CS was paired with the delivery of water. Nicotine was administered either prior to the first or last seven sessions, or throughout the entire conditioning procedure. Responding for conditioned reinforcement, extinction, and the reinstatement of responding by the stimulus and nicotine were compared across exposure groups. Separately, the effects of nicotine on conditioned approach toward a lever-CS during autoshaping, and responding for that CS as a conditioned reinforcer, were examined.
resultsNicotine exposure was necessary for nicotine-enhanced responding for conditioned reinforcement and the ability for nicotine and the stimulus to additively reinstate responding on the reinforced lever. Nicotine increased contacts with a lever-CS during autoshaping, and removal of nicotine abolished this effect. Prior nicotine exposure was necessary for nicotine-enhanced responding reinforced by the lever.
conclusionsEnhancements in the motivating properties of CSs by nicotine occur independently from duration and timing effects of nicotine exposure during conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.