Trial reportShock (Augusta, Ga.)2014
Plasma first in the field for postinjury hemorrhagic shock.
Trial report in Shock (Augusta, Ga.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- The efficacy and safety of pre-hospital plasma in patients at risk for hemorrhagic shock: an updated systematic review and meta-analysis of randomized controlled trials.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Pooled it
- Pre-hospital plasma in haemorrhagic shock management: current opinion and meta-analysis of randomized trials.World journal of emergency surgery : WJESPooled it
- Forgot calcium? Admission ionized-calcium in two civilian randomized controlled trials of prehospital plasma for traumatic hemorrhagic shock.The journal of trauma and acute care surgery · 2020Trial
- Trial
- Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial.Lancet (London, England) · 2018Trial
- Trial
- Taking the Blood Bank to the Field: The Design and Rationale of the Prehospital Air Medical Plasma (PAMPer) Trial.Prehospital emergency careTrial
- Massive transfusion and the response to prehospital plasma: It is all in how you define it.The journal of trauma and acute care surgery · 2020Article
- Article
- Fibrinogen Protects Against Barrier Dysfunction Through Maintaining Cell Surface Syndecan-1 In Vitro.Shock (Augusta, Ga.) · 2019Article
- The Role of Plasma Transfusion in Massive Bleeding: Protecting the Endothelial Glycocalyx?Frontiers in medicine · 2018Review
- Multicenter observational prehospital resuscitation on helicopter study.The journal of trauma and acute care surgery · 2017Observational
- Prehospital blood transfusions in pediatric trauma and nontrauma patients: a single-center review of safety and outcomes.Pediatric surgery international · 2017Article
- Optimal Fluid Therapy for Traumatic Hemorrhagic Shock.Critical care clinics · 2017Review
- Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock.Shock (Augusta, Ga.) · 2016Article
- Choice of Fluid Therapy in the Initial Management of Sepsis, Severe Sepsis, and Septic Shock.Shock (Augusta, Ga.) · 2016Review
- Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient.Transfusion · 2016Article
- Comprehensive US government program for dried plasma development.Transfusion · 2016Review
- Shock-induced systemic hyperfibrinolysis is attenuated by plasma-first resuscitation.The journal of trauma and acute care surgery · 2015Article
- Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics.Journal of translational medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Hemorrhage is the most preventable cause of death in civilian and military trauma, and despite tremendous advances in patient transport in the field, survival within the first hour has changed little over the past 40 years. The pathogenesis of trauma-induced coagulopathy is multifactorial, but most authorities believe there is an early depletion of clotting factors. While fresh frozen plasma delivered early in the emergency department has been shown to be beneficial, the rapid onset of trauma-induced coagulopathy suggests advancing this concept to the scene may improve patient outcome. The purpose of this report was to describe the rationale and design of a randomized trial to test the hypothesis that prehospital "plasma-first" resuscitation will benefit the critically injured patient. The rationale includes the possibility that plasma-first resuscitation may be advantageous beyond direct effects on clotting capacity. The study design is based on a ground ambulance system that allows rapid prehospital thawing of frozen plasma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.