ReviewVirulence2014
Metagenomics and novel gene discovery: promise and potential for novel therapeutics.
Review in Virulence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- A fast workflow to explore active enzymes from environmental samples through functional metagenomics.Applied microbiology and biotechnology · 2026Article
- Deploying Metagenomics to Characterize Microbial Pathogens During Outbreak of Acute Febrile Illness Among Children in Tanzania.Pathogens (Basel, Switzerland) · 2025Article
- Generation of ribosomal protein S1 mutants for improving of expression of difficult to translate mRNAs.Applied microbiology and biotechnology · 2025Article
- AMWEst, a new thermostable and detergent-tolerant esterase retrieved from the Albian aquifer.Applied microbiology and biotechnology · 2024Article
- Comparison of the urinary microbiome in men who have sex with men with and without Chlamydia trachomatis infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Integrated Macrogenomics and Metabolomics Explore Alterations and Correlation between Gut Microbiota and Serum Metabolites in Adult Epileptic Patients: A Pilot Study.Microorganisms · 2023Article
- South Africa's indigenous microbial diversity for industrial applications: A review of the current status and opportunities.Heliyon · 2023Review
- Advances in Microbiome-Derived Solutions and Methodologies Are Founding a New Era in Skin Health and Care.Pathogens (Basel, Switzerland) · 2022Review
- Potential Use of Microbial Community Genomes in Various Dimensions of Agriculture Productivity and Its Management: A Review.Frontiers in microbiology · 2022Review
- Discovery of novel carbohydrate degrading enzymes from soda lakes through functional metagenomics.Frontiers in microbiology · 2022Article
- A metagenomic insight into the Yangtze finless porpoise virome.Frontiers in veterinary science · 2022Article
- Current Status of Mining, Modification, and Application of Cellulases in Bioactive Substance Extraction.Current issues in molecular biology · 2021Review
- Marine Bacterial Esterases: Emerging Biocatalysts for Industrial Applications.Applied biochemistry and biotechnology · 2021Review
- Bacteriophages in Biological Wastewater Treatment Systems: Occurrence, Characterization, and Function.Frontiers in microbiology · 2021Review
- A sampling survey of enterococci within pasteurized, fermented dairy products and their virulence and antibiotic resistance properties.PloS one · 2021Article
- Metagenomic Studies in Inflammatory Skin Diseases.Current microbiology · 2020Review
- Metagenomic characterization of bacterial biofilm in four food processing plants in Colombia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- A comprehensive survey of integron-associated genes present in metagenomes.BMC genomics · 2020Article
- Sodium, hypertension, and the gut: does the gut microbiota go salty?American journal of physiology. Heart and circulatory physiology · 2019Review
- Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Viruses · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metagenomics provides a means of assessing the total genetic pool of all the microbes in a particular environment, in a culture-independent manner. It has revealed unprecedented diversity in microbial community composition, which is further reflected in the encoded functional diversity of the genomes, a large proportion of which consists of novel genes. Herein, we review both sequence-based and functional metagenomic methods to uncover novel genes and outline some of the associated problems of each type of approach, as well as potential solutions. Furthermore, we discuss the potential for metagenomic biotherapeutic discovery, with a particular focus on the human gut microbiome and finally, we outline how the discovery of novel genes may be used to create bioengineered probiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.