Evidence map›Paper›PMID 24317181›Full record

ArticleJournal of the National Cancer Institute2014

Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer.

Cecilie Kyrø, Anja Olsen, Rikard Landberg, Guri Skeie, Steffen Loft, Per Åman, Max Leenders, Vincent K Dik, Peter D Siersema, Tobias Pischon and 40 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. 5-Journal of agricultural and food chemistry · 2021
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  16. Biomarkers of cereal food intake.Genes & nutrition · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

50 authors.

Cecilie KyrøAffiliations of authors: Danish Cancer Society Research Center, Copenhagen, Denmark (CK, AO, JC, AT); Department of Food Science, BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden (RL, PÅ); Department of Community Medicine, University of Tromsø, Tromsø, Norway (GS, EW, TB, LAÅ); Department of Public Health, Section of Environmental Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark (SL); Department of Gastroenterology and Hepatology (ML, VKD, PDS, BB) and Department of Epidemiology, Julius Center for Health Sciences and Primary Care (PHP), University Medical Center Utrecht, Utrecht, The Netherlands; Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine Berlin-Buch, Berlin, Germany (TP); Department of Public Health, Section of Epidemiology, Aarhus University, Aarhus, Denmark (KO); Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805, Villejuif, France (M-CB-R, GF, VC); Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France (M-CB-R, GF, VC); IGR, F-94805, Villejuif, France (M-CB-R, GF, VC); German Cancer Research Center, DKFZ, Division of Cancer Epidemiology, Heidelberg, Germany (TK, JC-C); Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany (HB); Hellenic Health Foundation, Athens, Greece (ATR, CB, DT); WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece (ATR, CB); Department of Epidemiology, Harvard School of Public Health, Boston, MA (DT); Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece (DT); Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy (DP); Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (VK); Cancer Registry and His
Anja Olsen
Rikard Landberg
Guri Skeie
Steffen Loft
Per Åman
Max Leenders
Vincent K Dik
Peter D Siersema
Tobias Pischon
Jane Christensen
Kim Overvad
Marie-Christine Boutron-Ruault
Guy Fagherazzi
Vanessa Cottet
Tilman Kühn
Jenny Chang-Claude
Heiner Boeing
Antonia Trichopoulou
Christina Bamia
Dimitrios Trichopoulos
Domenico Palli
Vittorio Krogh
Rosario Tumino
Paolo Vineis
Salvatore Panico
Petra H Peeters
Elisabete Weiderpass
Toril Bakken
Lene Angell Åsli
Marcial Argüelles
Paula Jakszyn
María-José Sánchez
Pilar Amiano
José María Huerta
Aurelio Barricarte
Ingrid Ljuslinder
Richard Palmqvist
Kay-Tee Khaw
Nick Wareham
Timothy J Key
Ruth C Travis
Pietro Ferrari
Heinz Freisling
Mazda Jenab
Marc J Gunter
Neil Murphy
Eilo Riboli
Anne Tjønneland
H B as Bueno-de-Mesquita

Funding

Cancer Research UK 14136Cancer Research UK 16491Medical Research Council G0401527Medical Research Council G1000143
6 · The paper itself

Abstract

backgroundFew studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.

methodsThe association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal cancer incidence were investigated using prediagnostic plasma samples from colorectal cancer case patients and matched control subjects nested within the European Prospective Investigation into Cancer and Nutrition. We included 1372 incident colorectal cancer case patients and 1372 individual matched control subjects and calculated the incidence rate ratios (IRRs) for overall and anatomical subsites of colorectal cancer using conditional logistic regression adjusted for potential confounders. Regional differences (Scandinavia, the Mediterranean, Central Europe) were also explored.

resultsHigh plasma total alkylresorcinol concentration was associated with lower incidence of distal colon cancer; the adjusted incidence rate ratio of distal colon cancer for the highest vs lowest quartile of plasma total alkylresorcinols was 0.48 (95% confidence interval [CI] = 0.28 to 0.83). An inverse association between plasma total alkylresorcinol concentrations and colon cancer was found for Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to 0.98). However, plasma total alkylresorcinol concentrations were not associated with overall colorectal cancer, proximal colon cancer, or rectal cancer. Plasma alkylresorcinols concentrations were associated with colon and distal colon cancer only in Central Europe and Scandinavia (ie, areas where alkylresorcinol levels were higher).

conclusionsHigh concentrations of plasma alkylresorcinols were associated with a lower incidence of distal colon cancer but not with overall colorectal cancer, proximal colon cancer, and rectal cancer.

Indexed as

Feeding BehaviorSecaleTriticumAgedBiomarkersBody Mass IndexCase-Control StudiesColorectal NeoplasmsEuropeFemaleHumansIncidenceLogistic ModelsMaleMediterranean RegionMiddle AgedBiomarkersResorcinols

Identifiers

PMID24317181
PMCPMC3906988

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.