Evidence map›Paper›PMID 24317122›Full record

Trial reportBone marrow transplantation2014

Efficacy of exercise training in SCT patients--who benefits most?

J Wiskemann, R Kuehl, P Dreger, R Schwerdtfeger, G Huber, C M Ulrich, D Jaeger, M Bohus

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Bone marrow transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
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  5. Trial
  6. Safety and feasibility of electrical muscle stimulation in patients undergoing autologous and allogeneic stem cell transplantation or intensive chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Trial
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  8. Determinants of exercise adherence and contamination in a randomized controlled trial in cancer patients during and after allogeneic HCT.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016
    Trial
  9. Heart rate recovery and aerobic endurance capacity in cancer survivors: interdependence and exercise-induced improvements.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015
    Trial
  10. Exercise and stress management training prior to hematopoietic cell transplantation: Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2014
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

J Wiskemann1] National Center for Tumor Diseases (NCT), University Clinic Heidelberg, Heidelberg, Germany [2] National Center for Tumor Diseases (NCT), German Cancer Research Center, Heidelberg, Germany [3] Central Institute of Mental Health, Mannheim, Germany.
R KuehlNational Center for Tumor Diseases (NCT), German Cancer Research Center, Heidelberg, Germany.
P DregerDepartment of Medicine V, University of Heidelberg, Heidelberg, Germany.
R SchwerdtfegerGerman Clinic for Diagnostic, BMT Unit, Wiesbaden, Germany.
G HuberInstitute of Sports and Sport Science, University of Heidelberg, Heidelberg, Germany.
C M Ulrich1] National Center for Tumor Diseases (NCT), German Cancer Research Center, Heidelberg, Germany [2] Fred Hutchinson Cancer Research Centre, Seattle, WA, USA.
D JaegerNational Center for Tumor Diseases (NCT), University Clinic Heidelberg, Heidelberg, Germany.
M BohusCentral Institute of Mental Health, Mannheim, Germany.
Heidelberg University · DENational Center for Tumor Diseases · DECentral Institute of Mental Health · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients undergoing allo-HCT often experience a substantial loss in physical performance. We have recently published the general effectiveness of an exercise intervention in 105 allo-HCT patients on physical performance and psychosocial well-being. However, predictor variables for differentiated treatment response remained unclear. To determine the impact of basic physical performance on treatment response, we assessed muscle strength and endurance performance at four assessment points before and after allo-HCT. The exercise group started training 2 weeks before admission and ended 6-8 weeks after discharge. Comparing initially fit with unfit classified patients, the fit patients lost 31% of the strength of the knee-extensors, whereas the unfit patients lost only 1% (P<0.05). For endurance capacity, fit patients lost 4% of their walking capability, whereas unfit patients gained 13% (P<0.05). The individual percent change was statistically different at the 0.05 level in all measures of physical performance. Individual training response in allo-HCT patients strongly depends on the initial physical performance level. Unfit patients can be trained safely and may benefit more from this exercise intervention than fit patients. This result is of major clinical relevance and should encourage hematologists to promote exercise even more in impaired/unfit allo-HCT patients.

Indexed as

Hematopoietic Stem Cell TransplantationQuality of LifeAdolescentAdultAgedExercise TherapyFemaleHematologic NeoplasmsHumansMaleMiddle AgedMuscle StrengthProspective StudiesTransplantation, HomologousTreatment OutcomeWalking

Identifiers

PMID24317122
OpenAlexW2025598493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.