ArticleThe Journal of clinical investigation2014
Embryonic exposure to excess thyroid hormone causes thyrotrope cell death.
Article in The Journal of clinical investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Maternal TPO-Ab status modulates associations between gestational thyroid hormones and neonatal TSH in 10,154 Chinese mother-newborn pairs.Therapeutic advances in endocrinology and metabolism · 2026Article
- Insights into the role of Fsh signaling in ovarian differentiation ofZoological research · 2025Article
- A Novel Transgenic Model to Study Thyroid Axis Activity in Early Life Stage Medaka.Environmental science & technology · 2024Article
- A Mixture of Chemicals Found in Human Amniotic Fluid Disrupts Brain Gene Expression and Behavior inInternational journal of molecular sciences · 2023Article
- Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance.Endocrine connections · 2022Article
- Article
- Multiplex Analysis Platform for Endocrine Disruption Prediction Using Zebrafish.International journal of molecular sciences · 2019Article
- Intrafollicular thyroid hormone staining in whole-mount zebrafish (Danio rerio) embryos for the detection of thyroid hormone synthesis disruption.Fish physiology and biochemistry · 2018Article
- A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function.Scientific reports · 2018Article
- An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos.PloS one · 2018Article
- Low Thyroid Hormone Levels Disrupt Thyrotrope Development.Endocrinology · 2017Article
- How zebrafish research has helped in understanding thyroid diseases.F1000Research · 2017Review
- Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph.PloS one · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Central congenital hypothyroidism (CCH) is more prevalent in children born to women with hyperthyroidism during pregnancy, suggesting a role for thyroid hormone (TH) in the development of central thyroid regulation. Using the zebrafish embryo as a model for thyroid axis development, we have characterized the ontogeny of negative feedback regulation of thyrotrope function and examined the effect of excess TH on thyrotrope development. We found that thyroid-stimulating hormone β subunit (tshb) and type 2 deiodinase (dio2) are coexpressed in zebrafish thyrotropes by 48 hours after fertilization and that TH-driven negative feedback regulation of tshb transcription appears in the thyroid axis by 96 hours after fertilization. Negative feedback regulation correlated with increased systemic TH levels from the developing thyroid follicles. We used a transgenic zebrafish that expresses GFP under the control of the tshb promoter to follow thyrotrope fates in vivo. Time-lapse imaging revealed that early exposure to elevated TH leads to thyrotrope cell death. Thyrotrope numbers slowly recovered following the removal of excess TH. These data demonstrate that transient TH exposure profoundly impacts the thyrotrope population during a critical period of pituitary development and may have long-term implications for the functional reserve of thyroid-stimulating hormone (TSH) production and the TSH set point later in life.
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Registered trials
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