ReviewMedicina oral, patologia oral y cirugia bucal2014
Exclusion of PAX9 and MSX1 mutation in six families affected by tooth agenesis. A genetic study and literature review.
Review in Medicina oral, patologia oral y cirugia bucal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- [A Review of Archaeological Studies on Dento-maxillofacial Deformities].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- MSX1 and PAX9 Polymorphisms and Their Association With Lateral Incisor Morphology in Patients With Maxillary Canine Impaction.Medical science monitor : international medical journal of experimental and clinical research · 2026Observational
- Association between dental agenesis and facial morphology. A cross-sectional study in France.PloS one · 2024Observational
- Identification of novel candidate genes associated with non-syndromic tooth agenesis in Mongolian families.Clinical oral investigations · 2023Article
- Successful treatment modalities for missing lateral incisors- A systematic review.The Saudi dental journal · 2021Review
- Functional Analysis of Ectodysplasin-A Mutations in X-Linked Nonsyndromic Hypodontia and Possible Involvement of X-Chromosome Inactivation.Stem cells international · 2021Article
- Mutation analysis by direct and whole exome sequencing in familial and sporadic tooth agenesis.International journal of molecular medicine · 2016Article
- Epithelial - Mesenchymal Interactions in Tooth Development and the Significant Role of Growth Factors and Genes with Emphasis on Mesenchyme - A Review.Journal of clinical and diagnostic research : JCDR · 2016Review
- A Rare Incidence of Nonsyndromic Mandibular Incisor Agenesis in a Three-generation Family: Case Report and Literature Review.International journal of clinical pediatric dentistryArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn the present study, it is describe the phenotypical analysis and the mutational screening, for genes PAX9 and MSX1, of six families affected by severe forms of tooth agenesis associated with other dental anomalies and systemic entities. STUDY
designSix families affected by severe tooth agenesis associated with other dental anomalies and systemic entities were included. Oral exploration, radiological examination, medical antecedents consideration and mutational screening for PAX9 and MSX1 were carried out.
resultsNo mutations were discovered despite the fact that numerous teeth were missing. An important phenotypical variability was observed within the probands, not being possible to establish a parallelism with the patterns associated to previously described PAX9 and MSX1 mutations. CONCLUSIONS; These results bring us to conclude that probably other genes can determine phenotypical patterns of dental agenesis in the families studied, different than the ones described in the mutations of PAX9 and MSX1. Moreover, epigenetic factors can be involved, as those that can reduce gene dosage and other post-transcriptional modulation agents, causing dental agenesis associated or not with systemic anomalies.
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