Trial reportMedicina oral, patologia oral y cirugia bucal2014
Prospective double-blind clinical trial evaluating the effectiveness of Bromelain in the third molar extraction postoperative period.
Trial report in Medicina oral, patologia oral y cirugia bucal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms.Nutrients · 2024Pooled it
- Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials.Medicina oral, patologia oral y cirugia bucal · 2019Pooled it
- The effects of systemic proteolytic enzyme therapy on pain and swelling in third molar surgery equal to diclofenac therapy: a prospective randomized double blinded clinical trial.Oral and maxillofacial surgery · 2020Trial
- Efficacy of a drug composed of herbal extracts on postoperative discomfort after surgical removal of impacted mandibular third molar: a randomized, triple-blind, controlled clinical trial.Clinical oral investigations · 2019Trial
- A Comparative Evaluation of Efficacy of Minimally Invasive Mechanical and Chemomechanical Techniques for Dentinal Caries Removal in Primary Teeth: AnInternational journal of clinical pediatric dentistry · 2026Article
- Performance of complementary therapies in controlling inflammatory signs, symptoms, and complications after lower third molar extraction: a bibliometric analysis of the top 100 most-cited articles.Acta cirurgica brasileira · 2026Review
- The effect of bromelain-acetaminophen combination on the intensity of endodontic postoperative pain: A randomized clinical trial.Dental research journal · 2025Article
- Efficacy of a novel combination of aloe vera gel and pineapple extracts in improving post-extraction pain and healing: A Randomized Controlled Trial.Journal of clinical and experimental dentistry · 2024Article
- Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients.Journal of clinical medicine · 2024Article
- Effectiveness of Bromelain in the control of postoperative pain after periodontal surgery: A crossover randomized clinical trial.Journal of advanced periodontology & implant dentistry · 2023Article
- Therapeutic Efficacy of Bromelain in Alveolar Ridge Preservation.Antibiotics (Basel, Switzerland) · 2022Article
- Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial.Journal of dentistry (Tehran, Iran) · 2018Article
- Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor.Oncology letters · 2018Article
- Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars.Journal of International Society of Preventive & Community Dentistry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the anti-inflammatory and analgesic effect of Bromelain (pineapple extract) administered orally in the postoperative after extraction of impacted lower molars. STUDY
designThis is a prospective, placebo-controlled, unicentric, double-blind study; the sample size was 34 patients. The pre and postoperative outcomes, evaluated on the third (D3) and eighth day (D8), included inflamtion, pain and oral aperture, as well as the need for analgesics. One group received Bromelain 150mg per day for three days and 100mg on days 4 to 7. The other group received placebo in the same dosage. All outcomes werrecorded quantitatively and analyzed with the Mann-Whitney U test for independent samples.
resultsAlthough there were no statistically significant differences between the treatment groups, a trend towards less inflammation and improved oral aperture was observed in the group that received Bromelain, compared to the group that received placebo. This trend can be attributed completely to random reasons, since there is no statistical difference in the results.
conclusionsFurther studies are necessary to analyze different administration patterns and doses of Bromelain for the use in the postoperative of impacted third molars.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.