Trial reportEpigenetics2014
LINE1 methylation levels associated with increased bladder cancer risk in pre-diagnostic blood DNA among US (PLCO) and European (ATBC) cohort study participants.
Trial report in Epigenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Cigarette smoking and risk of bladder cancer: a dose-response meta-analysis.International urology and nephrology · 2022Pooled it
- Prospective study of DNA methylation at LINE-1 and Alu in peripheral blood and the risk of prostate cancer.The Prostate · 2015Trial
- A prospective study of smoking-related white blood cell DNA methylation markers and risk of bladder cancer.European journal of epidemiology · 2024Article
- The Role of DNA Methylation and DNA Methyltransferases in Cancer.Advances in experimental medicine and biology · 2022Article
- Modified CDKN2B (p15) and CDKN2A (p16) DNA methylation profiles in urban pesticide applicators.Environmental science and pollution research international · 2019Article
- Evaluation of DNA Methylation Changes and Micronuclei in Workers Exposed to a Construction Environment.International journal of environmental research and public health · 2019Observational
- Association of Sperm Methylation atFrontiers in genetics · 2019Article
- Methylation status of IGF2 DMR and LINE1 in leukocyte DNA provides distinct clinicopathological features of gastric cancer patients.Clinical and experimental medicine · 2018Article
- Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study.The Journal of pathology · 2017Article
- LINE-1 hypermethylation in white blood cell DNA is associated with high-grade cervical intraepithelial neoplasia.BMC cancer · 2017Article
- Pesticide use and LINE-1 methylation among male private pesticide applicators in the Agricultural Health Study.Environmental epigenetics · 2017Article
- World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung.Experimental and molecular pathology · 2017Article
- Relationships between Global DNA Methylation in Circulating White Blood Cells and Breast Cancer Risk Factors.Journal of cancer epidemiology · 2017Review
- Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case-control study.British journal of cancer · 2016Article
- Prospective changes in global DNA methylation and cancer incidence and mortality.British journal of cancer · 2016Article
- Detection of differential DNA methylation in repetitive DNA of mice and humans perinatally exposed to bisphenol A.Epigenetics · 2016Article
- Quantification of unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples.Oncotarget · 2016Article
- The Role of DNA Methylation in Cancer.Advances in experimental medicine and biology · 2016Review
- Disagreement between two common biomarkers of global DNA methylation.Clinical epigenetics · 2016Article
- The PLCO Biorepository: Creating, Maintaining, and Administering a Unique Biospecimen Resource.Reviews on recent clinical trials · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Global methylation in blood DNA has been associated with bladder cancer risk in case-control studies, but has not been examined prospectively. We examined the association between LINE1 total percent 5-methylcytosine and bladder cancer risk using pre-diagnostic blood DNA from the United States-based, Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial (PLCO) (299 cases/676 controls), and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) cohort of Finnish male smokers (391 cases/778 controls). Logistic regression adjusted for age at blood draw, study center, pack-years of smoking, and sex was used to estimate odd ratios (ORs) and 95% confidence intervals (CIs) using study- and sex-specific methylation quartiles. In PLCO, higher, although non-significant, bladder cancer risks were observed for participants in the highest three quartiles (Q2-Q4) compared with the lowest quartile (Q1) (OR = 1.36, 95% CI: 0.96 -1.92). The association was stronger in males (Q2-Q4 vs. Q1 OR = 1.48, 95% CI: 1.00-2.20) and statistically significant among male smokers (Q2-Q4 vs. Q1 OR = 1.83, 95% CI: 1.14-2.95). No association was found among females or female smokers. Findings for male smokers were validated in ATBC (Q2-Q4 vs. Q1: OR = 2.31, 95% CI: 1.62-3.30) and a highly significant trend was observed (P = 8.7 × 10(-7)). After determining that study data could be combined, pooled analysis of PLCO and ATBC male smokers (580 cases/1119 controls), ORs were significantly higher in Q2-Q4 compared with Q1 (OR = 2.03, 95% CI: 1.52-2.72), and a trend across quartiles was observed (P = 0.0001). These findings suggest that higher global methylation levels prior to diagnosis may increase bladder cancer risk, particularly among male smokers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.