ArticleNeuroscience2014
Impact of hippocampal neuronal ablation on neurogenesis and cognition in the aged brain.
Article in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Bibliometric analysis: Research trends of acupuncture treatment to cognitive impairment in recent 15 years.Frontiers in psychology · 2022Pooled it
- Neurogenesis and glial impairments in congenital hydrocephalus: insights from a BioGlue-induced fetal lamb model.Fluids and barriers of the CNS · 2025Article
- Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer's disease.Neural regeneration research · 2024Review
- Environmental enrichment in middle age rats improves spatial and object memory discrimination deficits.Frontiers in behavioral neuroscience · 2024Article
- Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum.Brain : a journal of neurology · 2023Article
- Co-Ultra PEALut Enhances Endogenous Repair Response Following Moderate Traumatic Brain Injury.International journal of molecular sciences · 2021Article
- Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose.Metabolic brain disease · 2021Article
- ExtracranialFrontiers in neuroscience · 2021Article
- Reproduction-Associated Hormones and Adult Hippocampal Neurogenesis.Neural plasticity · 2021Review
- Aggravated brain injury after neonatal hypoxic ischemia in microglia-depleted mice.Journal of neuroinflammation · 2020Article
- Article
- Born this way: Hippocampal neurogenesis across the lifespan.Aging cell · 2019Review
- Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice.Biological research · 2018Article
- Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.Molecular neurobiology · 2017Review
- Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity.Anesthesiology · 2016Article
- Bisphenol-A Mediated Inhibition of Hippocampal Neurogenesis Attenuated by Curcumin via Canonical Wnt Pathway.Molecular neurobiology · 2016Article
- Structure-function integrity of the adult hippocampus depends on the transcription factor Bcl11b/Ctip2.Genes, brain, and behavior · 2016Article
- Activity Dependency and Aging in the Regulation of Adult Neurogenesis.Cold Spring Harbor perspectives in biology · 2015Review
- Thyroid hormone signaling and adult neurogenesis in mammals.Frontiers in endocrinology · 2014Review
- Hippocampal adaptive response following extensive neuronal loss in an inducible transgenic mouse model.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Neuronal loss is the most common and critical feature of a spectrum of brain traumas and neurodegenerative disorders such as Alzheimer's disease (AD). The capacity to generate new neurons in the central nervous system diminishes early during brain development and is restricted mainly to two brain areas in the mature brain: subventricular zone and subgranular zone. Extensive research on the impact of brain injury on endogenous neurogenesis and cognition has been conducted primarily using young animals, when neurogenesis is most active. However, a critical question remains to elucidate the effect of brain injury on endogenous neurogenesis and cognition in older animals, which is far more relevant for age-related neurodegenerative disorders such as AD. Therefore, we examined the impact of neuronal loss on endogenous neurogenesis in aged animals using CaM/Tet-DTA mice, a transgenic model of hippocampal cell loss. Additionally, we investigated whether the upregulation of adult neurogenesis could mitigate cognitive deficits following substantial hippocampal neuronal loss. Our findings demonstrate that aged CaM/Tet-DTA mice that sustain severe neuronal loss exhibit an upregulation of endogenous neurogenesis. However, despite this significant upregulation, neurogenesis alone is not able to mitigate the cognitive deficits observed. Our studies suggest that the aged brain has the capacity to stimulate neurogenesis post-injury; however, multiple therapeutic approaches, including upregulation of endogenous neurogenesis, will be necessary to recover brain function after severe neurodegeneration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.