ReviewGeneral and comparative endocrinology2014
Evidence for intercellular communication in mosquito renal tubules: a putative role of gap junctions in coordinating and regulating the rapid diuretic effects of neuropeptides.
Review in General and comparative endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Fluid Secretion by Malpighian Tubules ofFrontiers in endocrinology · 2021Review
- Innexins: Expression, Regulation, and Functions.Frontiers in physiology · 2018Review
- Article
- Article
- The molecular and immunochemical expression of innexins in the yellow fever mosquito, Aedes aegypti: insights into putative life stage- and tissue-specific functions of gap junctions.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2015Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adult female mosquitoes require a blood meal from a vertebrate host to successfully reproduce. During a single blood feeding, a female may ingest more than the equivalent of her own body mass, resulting in an acute stress to osmotic and ionic homeostasis. In response to this stress, the renal (Malpighian) tubules mediate a rapid diuresis that commences as soon as blood is ingested. The diuresis is regulated by neuropeptides (e.g., kinins, calcitonin-like peptide) that act on receptors in the Malpighian tubule epithelium. Interestingly, the expression of these receptors is discontinuous throughout the epithelium, which raises the question as to how Malpighian tubules mount such a rapid and synchronized response to neuropeptide stimulation. Here we propose a hypothesis that gap junctions functionally couple the epithelial cells of Malpighian tubules, resulting in a coordinated physiological response to the binding of neuropeptides. We review recent, relevant literature on the electrophysiology, physiology, and molecular biology of mosquito Malpighian tubules that indicate the presence of gap junctions in the epithelium. We also provide new physiological and immunochemical data that are consistent with the proposed hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.