ArticleCurrent biology : CB2013
The unfolded protein response in a pair of sensory neurons promotes entry of C. elegans into dauer diapause.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
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- ER stress tolerance is regulated by copper-dependent PERK kinase activity.Cell reports · 2025Article
- The translation initiation factor eIF2α regulates lipid homeostasis and metabolic aging.Aging cell · 2025Article
- The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction inFrontiers in cell and developmental biology · 2023Article
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- Starvation Responses Throughout theGenetics · 2020Review
- ENPL-1, theDevelopment (Cambridge, England) · 2020Article
- Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues.PLoS genetics · 2020Article
- Ascaroside Pheromones: Chemical Biology and Pleiotropic Neuronal Functions.International journal of molecular sciences · 2019Review
- Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans.PLoS genetics · 2018Article
- Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation inGenetics · 2017Article
- A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism.Nature communications · 2017Article
- A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein.PLoS genetics · 2016Article
- Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans.PLoS genetics · 2016Article
- Sensory systems: their impact on C. elegans survival.Neuroscience · 2015Review
- It's all in your mind: determining germ cell fate by neuronal IRE-1 in C. elegans.PLoS genetics · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In response to unfavorable environmental conditions such as starvation, crowding, and elevated temperature, Caenorhabditis elegans larvae enter an alternative developmental stage known as dauer, which is characterized by adaptive changes in stress resistance and metabolism. The genetic dissection of the molecular mechanisms of the C. elegans dauer developmental decision has defined evolutionarily conserved signaling pathways of organismal neuroendocrine physiology. Here, we have identified a mechanism by which a dominant mutation in a neuronal insulin gene, daf-28(sa191), causes constitutive entry into dauer diapause. We demonstrate that expression of the mutant DAF-28 insulin peptide results in endoplasmic reticulum (ER) stress in the ASI pair of chemosensory neurons. The neuronal ER stress does not compromise cellular survival but activates PEK-1, the C. elegans ortholog of the mammalian eIF2α kinase PERK, which in turn phosphorylates Ser49 of eIF2α, specifically in the ASI neuron pair, to promote entry into dauer diapause. Our data establish a novel role for ER stress and the unfolded protein response (UPR) in promoting entry into dauer diapause and suggest that, in addition to cell-autonomous activities in the maintenance of ER homeostasis, the UPR may act in a non-cell-autonomous manner to promote organismal adaptation to stress during larval development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.