Evidence map›Paper›PMID 24316193›Full record

ArticleExperimental neurology2014

Axonal degeneration in dorsal columns of spinal cord does not induce recruitment of hematogenous macrophages.

Gang Zhang, Paul N Hoffman, Kazim A Sheikh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Role of Fcγ Receptor Mediated Inflammation in Immune Neuropathies.Journal of clinical & cellular immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Gang ZhangDepartment of Neurology, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA. Electronic address: gang.zhang@uth.tmc.edu.
Paul N HoffmanDepartment of Neurology, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address: phoffman@jhmi.edu.
Kazim A SheikhDepartment of Neurology, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA. Electronic address: kazim.sheikh@uth.tmc.edu.
The University of Texas Health Science Center at Houston · USJohns Hopkins University · US

Funding

Pathogenesis of Anti-ganglioside Antibody-Mediated NeuropathiesR01NS042888 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SHEIKH, KAZIM A · 2002 to 2016
$4.1M
Biologic effects of anti-ganglisiode antibodiesR01NS054962 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SHEIKH, KAZIM A · 2007 to 2018
$3.3M
NINDS NIH HHS R01 NS042888NINDS NIH HHS R01 NS054962NINDS NIH HHS R01 NS42888NINDS NIH HHS R01 NS54962
6 · The paper itself

Abstract

It is generally accepted that there are two populations of macrophages that respond to neural injuries and successful recruitment of hematogenous macrophages has been shown to help the process of nerve repair in the peripheral nervous system (PNS). Meanwhile, the recruitment of circulating macrophages after central nerve system (CNS) injuries is considered mild and delayed. We compared the recruitment of circulating macrophages in the peripheral nerves and spinal cord after dorsal root ganglionectomies, which induce selective and approximately similar extent of sensory fiber degeneration in PNS and CNS, in bone marrow chimeric mice. Our results showed that circulating macrophages were efficiently recruited in PNS but virtually no recruitment in CNS despite degeneration of peripheral and central sensory projections emanating from the same dorsal root ganglion (DRG) neurons. The mechanisms that prevent recruitment of circulating macrophages in CNS after injury remain poorly elucidated.

Indexed as

AnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBone Marrow TransplantationCD68 MoleculeCentral Nervous SystemCytokinesDisease Models, AnimalFlow CytometryGanglionectomyGreen Fluorescent ProteinsMacrophagesMiceMice, Inbred C57BLMice, TransgenicNerve DegenerationAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 antigen, humanCD68 MoleculeCytokinesGreen Fluorescent ProteinsAxonal degenerationBone marrow chimeric micecentral nerve systemChemokineCNSCytokinesdorsal root ganglionDorsal root ganglionectomyDRGFACSfluorescence-activated cell sortingGFPgreen fluorescent proteinHematogenous macrophage recruitmentPBMCsperipheral blood mononuclear cellsperipheral nerve systemPNS

Identifiers

PMID24316193
PMCPMC3970269
OpenAlexW1982688259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.