Evidence map›Paper›PMID 24315920›Full record

ArticleJournal of the American College of Cardiology2014

Reply: limits of Mendelian randomization analyses in selection of secretory phospholipase A2-IIA as a valid therapeutic target for prevention of cardiovascular disease.

Michael V Holmes, Tabassome Simon, Holly J Exeter, Aroon D Hingorani, Marc S Sabatine, Ziad Mallat, Juan P Casas, Philippa J Talmud

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Michael V Holmes
Tabassome Simon
Holly J Exeter
Aroon D Hingorani
Marc S Sabatine
Ziad Mallat
Juan P Casas
Philippa J Talmud

Funding

British Heart Foundation PG/09/022/26739Medical Research Council G0802432Medical Research Council MR/K006584/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression RegulationCardiovascular DiseasesDNAHumansMendelian Randomization AnalysisPhospholipases A2, SecretoryDNAPhospholipases A2, Secretory

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.