Evidence map›Paper›PMID 24315827›Full record

ReviewGastroenterology2014

Mechanisms of obesity-induced gastrointestinal neoplasia.

José O Alemán, Leonardo H Eusebi, Luigi Ricciardiello, Kavish Patidar, Arun J Sanyal, Peter R Holt

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03813381 (The Impact of a Moderate CAlorie and Protein REstriction PROgram), which is not on this map. Cited by 117 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03813381 nacompletednot on this mapstarted 2015, after this paper: background citation

The Impact of a Moderate CAlorie and Protein REstriction PROgram (CARE-PRO) as an Efficient and Affordable Therapeutic Strategy in Patients With Barrett's Esophagus.

TypeinterventionalSponsorIstituto Oncologico Veneto IRCCSRan2015 to 2021Enrolled160ConditionsBarrett's Esophagus, Overweight and ObesityArmsCalorie and protein restriction diet
3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
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  6. Pooled it
  7. Sex and Gender Perspective in Obesity and Gastric Cancer.The world journal of men's health · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. The obesity pandemic and its impact on non-communicable disease burden.Pflugers Archiv : European journal of physiology · 2025
    Review
  17. Loss ofTheranostics · 2025
    Article
  18. Article
  19. Review
  20. Article

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

José O Alemán *The Rockefeller University, New York, NY, USA.
Leonardo H EusebiDepartment of Medical and Surgical Sciences, University of Bologna, Italy.
Luigi RicciardielloDepartment of Medical and Surgical Sciences, and Center for Applied Biomedical Research (CRBA), University of Bologna, Italy.
Kavish PatidarVirginia Commonwealth University School of Medicine, Richmond, VA, USA.
Arun J SanyalVirginia Commonwealth University School of Medicine, Richmond, VA, USA.
Peter R Holt *The Rockefeller University, New York, NY, USA.

Funding

WOUND HEALING IN INDIVIDUALS OF DIFFERENT AGE AND GENETIC BACKGROUNDM01RR000102 · NCRR · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 1985 to 2006
$32.8M
Transforming Translational Science and Education to Benefit Human HealthUL1TR000043 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2012 to 2015
$26.8M
Training Grant in Digestive Diseases and Liver DiseasesT32DK007150 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SANYAL, ARUN J · 1986 to 2017
$4.2M
Molecular Determinants of Disease Progression in Nonalcoholic SteatohepatitisR01DK081410 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SANYAL, ARUN J · 2009 to 2013
$1.7M
NCATS NIH HHS 5UL1TR000043-08NCATS NIH HHS UL1 TR000043NCRR NIH HHS M01 RR000102NIDDK NIH HHS R01 DK 081410NIDDK NIH HHS R01 DK081410NIDDK NIH HHS T32 DK 007150NIDDK NIH HHS T32 DK007150
6 · The paper itself

Abstract

Obesity is among the fastest growing diseases worldwide; treatment is inadequate, and associated disorders, including gastrointestinal cancers, have high morbidity and mortality. An increased understanding of the mechanisms of obesity-induced carcinogenesis is required to develop methods to prevent or treat these cancers. In this report, we review the mechanisms of obesity-associated colorectal, esophageal, gastric, and pancreatic cancers and potential treatment strategies.

Indexed as

AdenocarcinomaBiomarkersDietGastrointestinal NeoplasmsGenetic Predisposition to DiseaseHumansInflammationIntestinesMicrobiotaObesityPancreatic NeoplasmsSignal TransductionBiomarkersBarrett's esophagusBEBMIbody mass indexcolorectal cancerColorectal CancerCRCEACesophageal adenocarcinomaEsophageal Cancergastric adenocarcinomaGastric CancergastrointestinalGCAGIIGFIGFBPIGFRILinsulin-like growth factorinsulin-like growth factor binding proteininsulin-like growth factor receptorinsulin receptorinterleukinIRlipopolysaccharidesLPSmammalian target of rapamycinMAPKMCP-1microsatellite instabilitymitogen-activated protein kinasemonocyte chemoattractant protein 1MSImTORPACpancreatic adenocarcinomaPancreatic Cancerrelative riskRRsoluble tumor necrosis factor receptor 2sTNFR2TNFtumor necrosis factor

Identifiers

PMID24315827
PMCPMC3978703

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.