ArticleHearing research2014
Sensorineural hearing loss amplifies neural coding of envelope information in the central auditory system of chinchillas.
Article in Hearing research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 74 citations in OpenAlex.
- Comparing physiological signatures of synaptopathic noise exposure and carboplatin-induced inner-hair-cell dysfunction in chinchillas.Hearing research · 2026Article
- Differentiating the Physiological Signatures of Cochlear Synaptopathy and Inner Hair Cell Damage in a Chinchilla Model.bioRxiv : the preprint server for biology · 2026Article
- Consequences and Mechanisms of Noise-Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Speech-in-noise discriminability after noise exposure: Insights from a gerbil model of acoustic trauma.PloS one · 2025Article
- Impact of reduced spectral resolution on temporal-coherence-based source segregation.The Journal of the Acoustical Society of America · 2024Article
- Article
- Impact of Reduced Spectral Resolution on Temporal-Coherence-Based Source Segregation.bioRxiv : the preprint server for biology · 2024Article
- Neural hyperactivity and altered envelope encoding in the central auditory system: Changes with advanced age and hearing loss.Hearing research · 2024Review
- Mitigation of Hearing Damage After Repeated Blast Exposures in Animal Model of Chinchilla.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- The Full Informational Spectral Analysis for Auditory Steady-State Responses in Human Brain Using the Combination of Canonical Correlation Analysis and Holo-Hilbert Spectral Analysis.Journal of clinical medicine · 2022Article
- Age-related deficits in dip-listening evident for isolated sentences but not for spoken stories.Scientific reports · 2022Article
- Distorted Tonotopy Severely Degrades Neural Representations of Connected Speech in Noise following Acoustic Trauma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Age-related hearing loss is associated with alterations in temporal envelope processing in different neural generators along the auditory pathway.Frontiers in neurology · 2022Article
- Noninvasive Measures of Distorted Tonotopic Speech Coding Following Noise-Induced Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Spectrally specific temporal analyses of spike-train responses to complex sounds: A unifying framework.PLoS computational biology · 2021Article
- Effects of Kainic Acid-Induced Auditory Nerve Damage on Envelope-Following Responses in the Budgerigar (Melopsittacus undulatus).Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Objective evidence of temporal processing deficits in older adults.Hearing research · 2020Review
- Effects of Sensorineural Hearing Loss on Cortical Synchronization to Competing Speech during Selective Attention.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Evolving perspectives on the sources of the frequency-following response.Nature communications · 2019Review
- The chinchilla animal model for hearing science and noise-induced hearing loss.The Journal of the Acoustical Society of America · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
People with sensorineural hearing loss often have substantial difficulty understanding speech under challenging listening conditions. Behavioral studies suggest that reduced sensitivity to the temporal structure of sound may be responsible, but underlying neurophysiological pathologies are incompletely understood. Here, we investigate the effects of noise-induced hearing loss on coding of envelope (ENV) structure in the central auditory system of anesthetized chinchillas. ENV coding was evaluated noninvasively using auditory evoked potentials recorded from the scalp surface in response to sinusoidally amplitude modulated tones with carrier frequencies of 1, 2, 4, and 8 kHz and a modulation frequency of 140 Hz. Stimuli were presented in quiet and in three levels of white background noise. The latency of scalp-recorded ENV responses was consistent with generation in the auditory midbrain. Hearing loss amplified neural coding of ENV at carrier frequencies of 2 kHz and above. This result may reflect enhanced ENV coding from the periphery and/or an increase in the gain of central auditory neurons. In contrast to expectations, hearing loss was not associated with a stronger adverse effect of increasing masker intensity on ENV coding. The exaggerated neural representation of ENV information shown here at the level of the auditory midbrain helps to explain previous findings of enhanced sensitivity to amplitude modulation in people with hearing loss under some conditions. Furthermore, amplified ENV coding may potentially contribute to speech perception problems in people with cochlear hearing loss by acting as a distraction from more salient acoustic cues, particularly in fluctuating backgrounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.