ArticleMetabolism: clinical and experimental2014
Diet quality is associated with circulating C-reactive protein but not irisin levels in humans.
Article in Metabolism: clinical and experimental, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- A systematic review and meta-analysis of loss-of-control eating in relation to cardiometabolic health components and inflammatory markers.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024Pooled it
- Dietary patterns and associations with biomarkers of inflammation in adults: a systematic review of observational studies.Nutrition journal · 2021Pooled it
- Association between Circulating Irisin and C-Reactive Protein Levels: A Systematic Review and Meta-Analysis.Endocrinology and metabolism (Seoul, Korea) · 2019Pooled it
- Trial
- Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk.Metabolism: clinical and experimental · 2014Trial
- Article
- Curcumin supplementation combined with high intensity interval training modulates serum irisin and lipid profile in obese women: "A randomized double-blind clinical trial".Contemporary clinical trials communications · 2025Article
- The role of dietary inflammation in the risk of osteoporosis in Iranian postmenopausal women: a case-control study.Scientific reports · 2025Article
- Nutritional Epigenomics: Bioactive Dietary Compounds in the Epigenetic Regulation of Osteoarthritis.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Article
- Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity.International journal of molecular sciences · 2023Review
- Eight-week exercise program improved the quality of life of Alzheimer's patients through functional, cognitive, and biochemical parameters.Irish journal of medical science · 2023Article
- Associations of healthy dietary patterns with mortality among people with prediabetes.European journal of nutrition · 2023Article
- The association between diet quality index-international and inflammatory markers in Iranian overweight and obese women.Frontiers in nutrition · 2023Article
- Association of plant-based diets with adropin, atherogenic index of plasma, and metabolic syndrome and its components: A cross-sectional study on adults.Frontiers in nutrition · 2023Article
- Changes of Circulating Irisin and High-Sensitivity C-Reactive Protein Levels in Morbidly Obese Individuals with Type 2 Diabetes After Roux-en-Y Gastric Bypass.Journal of laparoendoscopic & advanced surgical techniques. Part A · 2022Article
- Screening for Sarcopenia among Elderly Arab Females: Influence of Body Composition, Lifestyle, Irisin, and Vitamin D.Nutrients · 2022Article
- A Dietary Inflammatory Index and associations with C-reactive protein in a general adult population.European journal of nutrition · 2021Article
- Is Energy Expenditure or Physical Activity Considered When Energy Intake Is Measured? A Scoping Review 1975-2015.Nutrients · 2021Article
- The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue.Nutrients · 2021Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveAdherence to a healthy diet has been shown to decrease the incidence of obesity and associated comorbidities. C-reactive protein (CRP) is an established inflammatory marker and irisin was recently identified as a molecule which may play a role in energy regulation and obesity but whether diet alters irisin levels remains unknown. We aimed to investigate the association between circulating irisin, leptin, and CRP levels and dietary quantity and quality using the Alternate Healthy Eating Index (AHEI) and the Alternate Mediterranean Diet Score (aMED). MATERIALS/
methodsThe study evaluated dietary data and biomarker levels of 151 participants between 2009 and 2011 (71 male vs. 80 female, over 35 years old, obese 43.7%). AHEI and aMED scores were calculated based on data derived from self-administered 110-item food-frequency questionnaires estimating usual nutrient intake over the past year. Cross-sectional associations between dietary quantity, quality, body composition by bioelectric impedance, and biomarker levels including irisin, leptin, and CRP after fasting were assessed.
resultsCRP, but not irisin, was negatively correlated with AHEI (r=-0.34) and aMED (r=-0.31). Irisin was positively correlated with BMI (r=0.22), fat mass (r=0.21), waist circumference (r=0.24), waist-hip ratio (r=0.20), leptin (r=0.32), and CRP (r=0.25). Participants with the highest AHEI scores tended to have 11.6% lower concentrations of irisin (P for trend =0.09), but they were not significant after adjustment for potential confounders. Better diet quality was associated with lower CRP concentrations (P for trend=0.02) in multivariate model. Percentage of energy from carbohydrate was inversely associated with CRP.
conclusionsUnlike CRP, irisin is not associated with dietary quality or quantity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.