Evidence map›Paper›PMID 24315737›Full record

ArticleOral oncology2014

RAD51C--a new human cancer susceptibility gene for sporadic squamous cell carcinoma of the head and neck (HNSCC).

Kathrin Scheckenbach, Stephan E Baldus, Vera Balz, Marcel Freund, Petra Pakropa, Christoph Sproll, Karl-Ludwig Schäfer, Martin Wagenmann, Jörg Schipper, Helmut Hanenberg

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In one paragraph

Article in Oral oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
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  4. Annual review of genetics · 2020
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Kathrin ScheckenbachDepartment of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address: scheckenbach@med.uni-duesseldorf.de.
Stephan E BaldusDepartment of Pathology, Heinrich Heine University, 40225 Düsseldorf, Germany.
Vera BalzDepartment of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany.
Marcel FreundDepartment of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany.
Petra PakropaDepartment of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany.
Christoph SprollDepartment of Cranio-and-Maxillo Facial Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany.
Karl-Ludwig SchäferDepartment of Pathology, Heinrich Heine University, 40225 Düsseldorf, Germany.
Martin WagenmannDepartment of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany.
Jörg SchipperDepartment of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany.
Helmut HanenbergDepartment of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany; Pediatric Hematology/Oncology, Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Heinrich Heine University Düsseldorf · DE

Funding

Fanconi Anemia stem cells allow molecular characterization of acute leukemiaR01CA138237 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI BAGBY, GROVER CARLTON, CLAPP, DAVID W · 2008 to 2012
$1.9M
Genetic Therapy for Fanconi AnemiaR01CA155294 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI CLAPP, DAVID W, HANENBERG, HELMUT · 2011 to 2015
$1.6M
NCI NIH HHS CA155294-01NCI NIH HHS R01 CA138237NCI NIH HHS R01 CA138237-01NCI NIH HHS R01 CA155294
6 · The paper itself

Abstract

introductionHead and neck squamous cell carcinomas (HNSSCs) are one of the leading causes of cancer-associated death worldwide. Although certain behavioral risk factors are well recognized as tumor promoting, there is very little known about the presence of predisposing germline mutations in HNSCC patients.

methodsIn this study, we analyzed 121 individuals with HNSCCs collected at our institution for germline alterations in the newly identified cancer susceptibility gene RAD51C.

resultsSequencing of all exons and the adjacent introns revealed five distinct heterozygous sequence deviations in RAD51C in seven patients (5.8%). A female patient without any other risk factors carried a germline mutation that disrupted the canonical splice acceptor site of exon 5 (c.706-2A>G).

conclusionsAs there are only a few publications in the literature identifying germline mutations in head and neck cancer patients, our results provide the first indication that paralogs of RAD51, recently described as mutated in breast and ovarian cancer patients, might also be candidates for genetic risk factors in sporadic squamous cell carcinomas of the head and neck.

Indexed as

Genetic Predisposition to DiseaseGerm-Line MutationCarcinoma, Squamous CellDNA-Binding ProteinsDNA Mutational AnalysisExonsFemaleHead and Neck NeoplasmsHumansIntronsMaleRisk FactorsDNA-Binding ProteinsRAD51C protein, humanCancer susceptibility geneDNA repairGermline mutationsHead and neck cancerRAD51C

Identifiers

PMID24315737
PMCPMC4230275
OpenAlexW2037973914

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.