ArticleDrug and alcohol dependence2014
DSM-5 cannabis use disorder: a phenotypic and genomic perspective.
Article in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.Nature genetics · 2023Pooled it
- Genetic basis of cannabis use: a systematic review.BMC medical genomics · 2021Pooled it
- Associations Among Minority Stress, Relaxation and Tension-Reduction Motives, and Cannabis Use Among a Sample of Sexual and Gender Minority Adults in Oklahoma.Substance use & addiction journal · 2026Article
- Cannabis Use Differences Among Sexual Minority Versus Heterosexual Females and Males in Oklahoma: The Roles of Mental Health, Cannabis Perceptions, and Cannabis Marketing Exposure.Substance use & addiction journal · 2024Article
- Dimensionality and differential functioning of DSM-5 cannabis use disorder criteria in an online sample of adults with frequent cannabis use.Journal of psychiatric research · 2023Article
- Phytocannabinoids Biosynthesis in Angiosperms, Fungi, and Liverworts and Their Versatile Role.Plants (Basel, Switzerland) · 2021Review
- Sexual Minority Status and Marijuana Initiation during Adulthood: A Longitudinal Study Using Nationally Representative Data.Substance use & misuse · 2021Article
- Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects.Frontiers in pharmacology · 2020Review
- Genome-wide association study implicates CHRNA2 in cannabis use disorder.Nature neuroscience · 2019Article
- Exploring the relationship between polygenic risk for cannabis use, peer cannabis use and the longitudinal course of cannabis involvement.Addiction (Abingdon, England) · 2019Article
- The Cannabis Abuse Screening Test and the DSM-5 in the general population: Optimal thresholds and underlying common structure using multiple factor analysis.International journal of methods in psychiatric research · 2018Article
- A genome-wide association study of social genetic effects in Landrace pigs.Asian-Australasian journal of animal sciences · 2018Article
- Genome-wide association study identifies a novel locus for cannabis dependence.Molecular psychiatry · 2018Article
- Human Genetics of Addiction: New Insights and Future Directions.Current psychiatry reports · 2018Review
- Gene variants and educational attainment in cannabis use: mediating role of DNA methylation.Translational psychiatry · 2018Article
- Whole genome sequence study of cannabis dependence in two independent cohorts.Addiction biology · 2018Article
- Developmentally Specific Associations Between CNR1 Genotype and Cannabis Use Across Emerging Adulthood.Journal of studies on alcohol and drugs · 2017Article
- KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex.Addiction biology · 2016Article
- Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans.Drug and alcohol dependence · 2016Article
- Genetic and Environmental Factors Associated with Cannabis Involvement.Current addiction reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 10 institutions in 2 countries.
Funding
Abstract
backgroundWe explore the factor structure of DSM-5 cannabis use disorders, examine its prevalence across European- and African-American respondents as well as its genetic underpinnings, utilizing data from a genome-wide study of single nucleotide polymorphisms (SNPs). We also estimate the heritability of DSM-5 cannabis use disorders explained by these common SNPs.
methodsData on 3053 subjects reporting a lifetime history of cannabis use were utilized. Exploratory and confirmatory factor analyses were conducted to create a factor score, which was used in a genome-wide association analysis. p-values from the single SNP analysis were examined for evidence of gene-based association. The aggregate effect of all SNPs was also estimated using Genome-Wide Complex Traits Analysis.
resultsThe unidimensionality of DSM-5 cannabis use disorder criteria was demonstrated. Comparing DSM-IV to DSM-5, a decrease in prevalence of cannabis use disorders was only noted in European-American respondents and was exceedingly modest. For the DSM-5 cannabis use disorders factor score, no SNP surpassed the genome-wide significance testing threshold. However, in the European-American subsample, gene-based association testing resulted in significant associations in 3 genes (C17orf58, BPTF and PPM1D) on chromosome 17q24. In aggregate, 21% of the variance in DSM-5 cannabis use disorders was explained by the genome-wide SNPs; however, this estimate was not statistically significant.
conclusionsDSM-5 cannabis use disorder represents a unidimensional construct, the prevalence of which is only modestly elevated above the DSM-IV version. Considerably larger sample sizes will be required to identify individual SNPs associated with cannabis use disorders and unequivocally establish its polygenic underpinnings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.