Evidence map›Paper›PMID 24315395›Full record

ArticleUltrasound in medicine & biology2014

Ex Vivo characterization of canine liver tissue viscoelasticity after high-intensity focused ultrasound ablation.

Danial Shahmirzadi, Gary Y Hou, Jiangang Chen, Elisa E Konofagou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Heating technology for malignant tumors: a review.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2020
    Review
  3. Article
  4. Article
  5. Bubble-Induced Color Doppler Feedback for Histotripsy Tissue Fractionation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2016
    Article
  6. Article
  7. Article
  8. Article
  9. Thermometry and ablation monitoring with ultrasound.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2015
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Danial ShahmirzadiUltrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York, USA.
Gary Y HouUltrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York, USA.
Jiangang ChenUltrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York, USA.
Elisa E KonofagouUltrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York, USA; Department of Radiology, Columbia University, New York, New York, USA. Electronic address: ek2191@columbia.edu.

Funding

Ultrasound-based tumor targeting and thermal ablation monitoring systemR01EB014496 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2011 to 2014
$1.4M
A NOVEL SYSTEM FOR SIMULTANEOUS GENERATION AND MONITORING OF TUMOR ABLATIONR21EB008521 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2008 to 2009
$419k
Electroosmotic Pump for Microchip HPLCR21EB008512 · NIBIB · UNIVERSITY OF OKLAHOMA · PI LIU, SHAORONG · 2008 to 2009
$396k
NIBIB NIH HHS R01 EB014496NIBIB NIH HHS R21 EB008512NIBIB NIH HHS R21 EB008521
6 · The paper itself

Abstract

The potential of elasticity imaging to detect high-intensity focused ultrasound (HIFU) lesions on the basis of their distinct biomechanical properties is promising. However, information on the quantitative mechanical properties of the tissue and the optimal intensity at which to determine the best contrast parameters is scarce. In this study, fresh canine livers were ablated using combinations of ISPTA intensities of 5.55, 7.16 and 9.07 kW/cm(2) and durations of 10 and 30 s ex vivo, resulting in six groups of ablated tissues. Biopsy samples were then interrogated using dynamic shear mechanical testing within the range of 0.1-10 Hz to characterize the tissue's post-ablation viscoelastic properties. All mechanical parameters were found to be frequency dependent. Compared with unablated cases, all six groups of ablated tissues had statistically significant higher complex shear modulus and shear viscosity. However, among the ablated groups, both complex shear modulus and shear viscosity were found to monotonically increase in groups 1-4 (5.55 kW/cm(2) for 10 s, 7.16 kW/cm(2) for 10 s, 9.07 kW/cm(2) for 10 s, and 5.55 kW/cm(2) for 30 s, respectively), but to decrease in groups 5 and 6 (7.16 kW/cm(2) for 30 s, and 9.07 kW/cm(2) for 30 s, respectively). For groups 5 and 6, the temperature was expected to exceed the boiling point, and therefore, the decreased stiffening could be due to the compromised integrity of the tissue microstructure. Future studies will entail estimation tissue mechanical properties in vivo and perform real-time monitoring of tissue alterations during ablation.

Indexed as

AnimalsDogsElasticity Imaging TechniquesElastic ModulusHardnessHepatectomyHigh-Intensity Focused Ultrasound AblationImage Interpretation, Computer-AssistedIn Vitro TechniquesLiverReproducibility of ResultsSensitivity and SpecificityShear StrengthViscosityCanine liverElasticity imagingHarmonic motion imaging for focused ultrasoundHigh-intensity focused ultrasoundThermal ablationViscoelasticity

Identifiers

PMID24315395
PMCPMC4005882

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.