SynthesisAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2014
The landscape of clinical trials in nephrology: a systematic review of Clinicaltrials.gov.
Synthesis in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04334707 (Kidney Precision Medicine Project), which is not on this map. Cited by 81 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Kidney Precision Medicine Project
Who cites it
81 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements.Nature communications · 2024Pooled it
- Pooled it
- Patient-Centred Outcomes in Anaemia and Renal Disease: A Systematic Review.Kidney diseases (Basel, Switzerland) · 2020Pooled it
- A catalog of genetic loci associated with kidney function from analyses of a million individuals.Nature genetics · 2019Pooled it
- Impact of random variation in albuminuria and estimated glomerular filtration rate on patient enrolment and duration of clinical trials in nephrology.Diabetes, obesity & metabolism · 2022Trial
- The Primary-Secondary Care Partnership to Improve Outcomes in Chronic Kidney Disease (PSP-CKD) Study: A Cluster Randomized Trial in Primary Care.Journal of the American Society of Nephrology : JASN · 2019Trial
- The TiME Trial: A Fully Embedded, Cluster-Randomized, Pragmatic Trial of Hemodialysis Session Duration.Journal of the American Society of Nephrology : JASN · 2019Trial
- Efficacy of galactose and adalimumab in patients with resistant focal segmental glomerulosclerosis: report of the font clinical trial group.BMC nephrology · 2015Trial
- Approach to Quality Control Used for the HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Priorities for Evidence-Based CKD Guidance Using Delphi Methods.Kidney international reports · 2026Article
- Review no. 1: designing clinical kidney research using real-world data: research questions, data sources, and analytical skills.Clinical and experimental nephrology · 2026Review
- Marginal Improvements in Risk of Bias of Nephrology Randomized Controlled Trials Over Time: A Meta-research Study of Cochrane Reviews of Randomized Controlled Trials.Kidney medicine · 2026Article
- Reporting Quality of Randomized Controlled Trials in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis.Kidney international reports · 2025Article
- Benchmarking Transformer Embedding Models for Biomedical Terminology Standardization.Machine learning with applications · 2025Article
- Statistical consideration in nephrology research.Kidney research and clinical practice · 2025Article
- Demographic disparities in access to COVID-19 clinical trial sites across the United States: a geospatial analysis.International journal for equity in health · 2025Article
- Gender Differences in Citation Rate: An Analysis of Randomized Controlled Trials in Nephrology High-Impact Journals Over Two Decades.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- Nephrology Clinical Trials in Learning Health Systems: The Registry-Based Randomized Clinical Trial.Journal of the American Society of Nephrology : JASN · 2024Article
- An urgent call for environmental accountability in nephrology clinical trials.Clinical kidney journal · 2024Article
- Integrated multi-omics with machine learning to uncover the intricacies of kidney disease.Briefings in bioinformatics · 2024Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundWell-designed trials are of paramount importance in improving the delivery of care to patients with kidney disease. However, it remains unknown whether contemporary clinical trials within nephrology are of sufficient quality and quantity to meet this need. STUDY
designSystematic review. SETTING & POPULATION: Studies registered with ClinicalTrials.gov. SELECTION CRITERIA FOR STUDIES: Interventional (ie, nonobservational) studies (both randomized and nonrandomized) registered between October 2007 and September 2010 were included for analysis. Studies were reviewed independently by physicians and classified by clinical specialty. PREDICTOR: Nephrology versus cardiology versus other trials. OUTCOMES: Select clinical trial characteristics.
resultsOf 40,970 trials overall, 1,054 (2.6%) were classified as nephrology. Most nephrology trials were for treatment (75.4%) or prevention (15.7%), with very few diagnostic, screening, or health services research studies. Most nephrology trials were randomized (72.3%). Study designs included 24.9% with a single study group, 64.0% that included parallel groups, and 9.4% that were crossover trials. Nephrology trials, compared with 2,264 cardiology trials (5.5% overall), were more likely to be smaller (64.5% vs 48.0% enrolling≤100 patients), phases 1-2 (29.0% vs 19.7%), and unblinded (66.2% vs 53.3%; P<0.05 for all). Nephrology trials also were more likely than cardiology trials to include a drug intervention (72.4% vs 41.9%) and less likely to report having a data monitoring committee (40.3% vs 48.5%; P<0.05 for all). Finally, there were few trials funded by the National Institutes of Health (NIH; 3.3%, nephrology; 4.2%, cardiology). LIMITATIONS: Does not include all trials performed worldwide, and frequent categorization of funding source as university may underestimate NIH support.
conclusionsCritical differences remain between clinical trials in nephrology and other specialties. Improving care for patients with kidney disease will require a concerted effort to increase the scope, quality, and quantity of clinical trials within nephrology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.