Evidence map›Paper›PMID 24315019›Full record

ArticleEpilepsy research2014

Clinical value of magnetoencephalographic spike propagation represented by spatiotemporal source analysis: correlation with surgical outcome.

Naoaki Tanaka, Jurriaan M Peters, Anna K Prohl, Shigetoshi Takaya, Joseph R Madsen, Blaise F Bourgeois, Barbara A Dworetzky, Matti S Hämäläinen, Steven M Stufflebeam

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Magnetoencephalographic Mapping of Epileptic Spike Population Using Distributed Source Analysis: Comparison With Intracranial Electroencephalographic Spikes.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2018
    Article
  6. Review
  7. Article
  8. Characterization of Electrophysiological Propagation by Multichannel Sensors.IEEE transactions on bio-medical engineering · 2016
    Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Naoaki TanakaAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA 02129, USA. Electronic address: naoro@nmr.mgh.harvard.edu.
Jurriaan M PetersDivision of Epilepsy and Clinical Neurophysiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Anna K ProhlDivision of Epilepsy and Clinical Neurophysiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Shigetoshi TakayaAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA 02129, USA.
Joseph R MadsenDepartment of Neurosurgery, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Blaise F BourgeoisDivision of Epilepsy and Clinical Neurophysiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Barbara A DworetzkyDepartment of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Matti S HämäläinenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA 02129, USA.
Steven M StufflebeamAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA 02129, USA.
Boston Children's Hospital · USMassachusetts General Hospital · USBrigham and Women's Hospital · US

Funding

Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Functional Connectivity of Intrinsic Brain Activity for Presurgical MappingR01NS069696 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI STUFFLEBEAM, STEVEN · 2011 to 2015
$2.9M
Elekta Neuromag Electronics UpgradeS10RR031599 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI HAMALAINEN, MATTI · 2011 to 2011
$350k
NCRR NIH HHS S10RR014978NCRR NIH HHS S10 RR031599NIBIB NIH HHS P41 EB015896NIBIB NIH HHS P41EB015896NINDS NIH HHS 1R01NS069696-01A1NINDS NIH HHS R01 NS069696
6 · The paper itself

Abstract

objectiveTo investigate the correlation between spike propagation represented by spatiotemporal source analysis of magnetoencephalographic (MEG) spikes and surgical outcome in patients with temporal lobe epilepsy.

methodsThirty-seven patients were divided into mesial (n=27) and non-mesial (n=10) groups based on the presurgical evaluation. In each patient, ten ipsilateral spikes were averaged, and spatiotemporal source maps of the averaged spike were obtained by using minimum norm estimate. Regions of interest (ROIs) were created including temporoparietal, inferior frontal, mesial temporal, anterior and posterior part of the lateral temporal cortex. We extracted activation values from the source maps and the threshold was set at half of the maximum activation at the peak latency. The leading and propagated areas of the spike were defined as those ROIs with activation reaching the threshold at the earliest and at the peak latencies, respectively. Surgical outcome was assessed based on Engel's classification. Binary variables were created from leading areas (restricted to the anterior and mesial temporal ROIs or not) and from propagation areas (involving the temporoparietal ROI or not), and for surgical outcome (Class I or not). Fisher's exact test was used for significance testing.

resultsIn total and mesial group, restricted anterior/mesial temporal leading areas were correlated with Class I (p<0.05). Temporoparietal propagation was correlated with Class II-IV (p<0.05). For the non-mesial group, no significant relation was found.

conclusionsSpike propagation patterns represented by spatiotemporal source analysis of MEG spikes may provide useful information for prognostic implication in presurgical evaluation of epilepsy.

Indexed as

Action PotentialsAdolescentAdultAgedElectroencephalographyEpilepsy, Temporal LobeFemaleHumansMagnetoencephalographyMaleMiddle AgedRetrospective StudiesTime FactorsTreatment OutcomeYoung AdultEpilepsy surgeryMagnetoencephalography (MEG)Minimum norm estimate (MNE)Spike propagationTemporal lobe epilepsy

Identifiers

PMID24315019
PMCPMC3933022
OpenAlexW2014301207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.