ArticleNeuron2013
A modular gain-of-function approach to generate cortical interneuron subtypes from ES cells.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Comparative analysis of the cellular landscape in mammalian striatum.Nature communications · 2026Article
- Reverse engineering neuron-type-specific and type-orthogonal splicing-regulatory networks using diverse cellular transcriptomes.Cell reports · 2025Article
- The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.Developmental biology · 2023Article
- St18 specifies globus pallidus projection neuron identity in MGE lineage.Nature communications · 2022Article
- Human stem cell-derived GABAergic neurons functionally integrate into human neuronal networks.Scientific reports · 2021Article
- Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease.Stem cell reports · 2021Article
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- Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application.Frontiers in cell and developmental biology · 2021Review
- Interneuron Types as Attractors and Controllers.Annual review of neuroscience · 2020Review
- Article
- Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors.Frontiers in neuroscience · 2019Review
- Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3.Psychoneuroendocrinology · 2018Article
- Characterization of Glcci1 expression in a subpopulation of lateral ganglionic eminence progenitors in the mouse telencephalon.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors.Journal of visualized experiments : JoVE · 2017Article
- Cortical interneuron development: a tale of time and space.Development (Cambridge, England) · 2017Review
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Article
- Generation of pure GABAergic neurons by transcription factor programming.Nature methods · 2017Article
- Discovering sparse transcription factor codes for cell states and state transitions during development.eLife · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Whereas past work indicates that cortical interneurons (cINs) can be generically produced from stem cells, generating large numbers of specific subtypes of this population has remained elusive. This reflects an information gap in our understanding of the transcriptional programs required for different interneuron subtypes. Here, we have utilized the directed differentiation of stem cells into specific subpopulations of cortical interneurons as a means to identify some of these missing factors. To establish this approach, we utilized two factors known to be required for the generation of cINs, Nkx2-1 and Dlx2. As predicted, their regulated transient expression greatly improved the differentiation efficiency and specificity over baseline. We extended upon this "cIN-primed" model in order to establish a modular system whereby a third transcription factor could be systematically introduced. Using this approach, we identified Lmo3 and Pou3f4 as genes that can augment the differentiation and/or subtype specificity of cINs in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.