ArticleBiomaterials2014
Maximizing cartilage formation and integration via a trajectory-based tissue engineering approach.
Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Stage-specific MSC spheroid fusion enables bottom-up formation of stage-defined hierarchical cartilage graft.Materials today. Bio · 2026Article
- Ovine Mesenchymal Stem Cell Chondrogenesis on a Novel 3D-Printed Hybrid Scaffold In Vitro.Bioengineering (Basel, Switzerland) · 2024Article
- Co-culture pellet of human Wharton's jelly mesenchymal stem cells and rat costal chondrocytes as a candidate for articular cartilage regeneration: in vitro and in vivo study.Stem cell research & therapy · 2022Article
- Article
- Article
- The porcine accessory carpal bone as a model for biologic joint replacement for trapeziometacarpal osteoarthritis.Acta biomaterialia · 2021Article
- Mechano-activated biomolecule release in regenerating load-bearing tissue microenvironments.Biomaterials · 2021Article
- IGF-1-releasing PLGA nanoparticles modified 3D printed PCL scaffolds for cartilage tissue engineering.Drug delivery · 2020Article
- Restoration of osteochondral defects by implanting bilayered poly(lactide-Journal of orthopaedic translation · 2019Article
- Enzyme Pretreatment plus Locally Delivered HB-IGF-1 Stimulate Integrative Cartilage RepairTissue engineering. Part A · 2019Article
- Lithium Chloride-Releasing 3D Printed Scaffold for Enhanced Cartilage Regeneration.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Mechanically-Activated Microcapsules for 'On-Demand' Drug Delivery in Dynamically Loaded Musculoskeletal Tissues.Advanced functional materials · 2019Article
- Sprifermin treatment enhances cartilage integration in an in vitro repair model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Towards the scale up of tissue engineered intervertebral discs for clinical application.Acta biomaterialia · 2018Article
- Near-Infrared Spectroscopy Predicts Compositional and Mechanical Properties of Hyaluronic Acid-Based Engineered Cartilage Constructs.Tissue engineering. Part A · 2018Article
- Review
- In Vitro Maturation and In Vivo Integration and Function of an Engineered Cell-Seeded Disc-like Angle Ply Structure (DAPS) for Total Disc Arthroplasty.Scientific reports · 2017Article
- Rise of the Pigs: Utilization of the Porcine Model to Study Musculoskeletal Biomechanics and Tissue Engineering During Skeletal Growth.Tissue engineering. Part C, Methods · 2017Article
- Biphasic Finite Element Modeling Reconciles Mechanical Properties of Tissue-Engineered Cartilage Constructs Across Testing Platforms.Tissue engineering. Part A · 2017Article
- Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties.The Analyst · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Given the limitations of current surgical approaches to treat articular cartilage injuries, tissue engineering (TE) approaches have been aggressively pursued. Despite reproduction of key mechanical attributes of native tissue, the ability of TE cartilage constructs to integrate with native tissue must also be optimized for clinical success. In this paper, we propose a "trajectory-based" tissue engineering (TB-TE) approach, based on the hypothesis that time-dependent increases in construct maturation in-vitro prior to implantation (i.e. positive rates) may provide a reliable predictor of in-vivo success. As an example TE system, we utilized hyaluronic acid hydrogels laden with mesenchymal stem cells. We first modeled the maturation of these constructs in-vitro to capture time-dependent changes. We then performed a sensitivity analysis of the model to optimize the timing and amount of data collection. Finally, we showed that integration to cartilage in-vitro is not correlated to the maturation state of TE constructs, but rather their maturation rate, providing a proof-of-concept for the use of TB-TE to enhance treatment outcomes following cartilage injury. This new approach challenges the traditional TE paradigm of matching only native state parameters of maturity and emphasizes the importance of also establishing an in-vitro trajectory in constructs in order to improve the chance of in-vivo success.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.