ArticleClinical epigenetics2013
Interaction of prenatal maternal smoking, interleukin 13 genetic variants and DNA methylation influencing airflow and airway reactivity.
Article in Clinical epigenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second-generation offspring.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?International journal of environmental research and public health · 2021Review
- Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach.The European respiratory journal · 2021Article
- BMI trajectory in childhood is associated with asthma incidence at young adulthood mediated by DNA methylation.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Article
- Sex-specific longitudinal association of DNA methylation with lung function.ERJ open research · 2021Article
- Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review.International journal of environmental research and public health · 2021Review
- Associations among phthalate exposure, DNA methylation of TSLP, and childhood allergy.Clinical epigenetics · 2021Article
- Changes of DNA methylation are associated with changes in lung function during adolescence.Respiratory research · 2020Article
- Cohort Profile: The Isle Of Wight Whole Population Birth Cohort (IOWBC).International journal of epidemiology · 2018Observational
- A three-generation study on the association of tobacco smoking with asthma.International journal of epidemiology · 2018Article
- Prenatal environmental tobacco smoke exposure increases allergic asthma risk with methylation changes in mice.Environmental and molecular mutagenesis · 2017Article
- Constitutional Epi/Genetic Conditions: Genetic, Epigenetic, and Environmental Factors.Journal of pediatric genetics · 2017Review
- Multigenerational cohorts in patients with asthma and allergy.The Journal of allergy and clinical immunology · 2017Review
- Article
- Observational
- Inter- and transgenerational epigenetic inheritance: evidence in asthma and COPD?Clinical epigenetics · 2015Article
- Early origins of chronic obstructive lung diseases across the life course.European journal of epidemiology · 2014Review
- Oral contraceptives modify the effect of GATA3 polymorphisms on the risk of asthma at the age of 18 years via DNA methylation.Clinical epigenetics · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAsthma is characterized by airflow limitation and airway reactivity (AR). Interleukin-13 (IL-13) is involved in the pathogenesis of asthma. Two functional SNPs, rs20541 and rs1800925, of the IL-13 gene (IL13) have been frequently associated with asthma-related lung functions. However, genetic variation alone does not fully explain asthma risk. DNA-methylation (DNA-M) is an epigenetic mechanism that regulates gene expression and can be influenced by both environment and genetic variants. To explore the interplay of prenatal maternal smoking, genetic variants and DNA-M, we used a two-stage model: (1) identifying cytosine phosphate guanine (CpG) sites where DNA-M is influenced by the interaction between genetic variants and maternal smoking during pregnancy (conditional methQTL (methylation quantitative trait loci)); and (2) determining the effect of the interaction between DNA-M of CpG (from stage 1) and SNPs (modifying genetic variants; modGV) on airflow limitation and AR in 245 female participants of the Isle of Wight birth cohort. DNA-M was assessed using the Illumina Infinium HumanMethylation450 BeadChip.
findingsSix CpG sites were analyzed in stage 1. DNA-M at cg13566430 was influenced by interaction of maternal smoking during pregnancy and rs20541. In stage 2, genotype at rs1800925 interacted with DNA-M at cg13566430 significantly affecting airflow limitation (P = 0.042) and AR (P = 0.01).
conclusionBoth genetic variants and environment affect DNA-M. This study supports the proposed two-stage model (methQTL and modGV) to study genetic variants, environment and DNA-M interactions in asthma-related lung function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.