ArticleEnvironmental health : a global access science source2013
Traffic-related exposures and biomarkers of systemic inflammation, endothelial activation and oxidative stress: a panel study in the US trucking industry.
Article in Environmental health : a global access science source, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 73 citations in OpenAlex.
- Acute exposure to traffic-related air pollution alters antioxidant status in healthy adults.Environmental research · 2020Trial
- Particulate metal exposures induce plasma metabolome changes in a commuter panel study.PloS one · 2018Trial
- A Novel Immune-Related Three-Gene Signature and Immune Infiltration Insights in Psoriasis and Chronic Kidney Disease.Clinical, cosmetic and investigational dermatology · 2025Article
- Air Pollution and Interstitial Lung Disease.Tuberculosis and respiratory diseases · 2025Article
- Vitamin D3 regulates PM-driven primary human neutrophil inflammatory responses.Scientific reports · 2023Article
- Integrated molecular response of exposure to traffic-related pollutants in the US trucking industry.Environment international · 2022Article
- Interstitial Lung Diseases and Air Pollution: Narrative Review of Literature.Pulmonary therapy · 2021Review
- Chemical Biomarkers of Exposure and Early Damage from Potentially Carcinogenic Airborne Pollutants.Annals of cancer epidemiology · 2019Article
- Air Pollution Contributes to Asthma Deaths.American journal of respiratory and critical care medicine · 2019Article
- Roadside Exposure and Inflammation Biomarkers among a Cohort of Traffic Police in Kathmandu, Nepal.International journal of environmental research and public health · 2019Article
- Interstitial Lung Diseases in Developing Countries.Annals of global health · 2019Review
- PMInternational journal of biological sciences · 2019Article
- Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome.American journal of respiratory and critical care medicine · 2018Article
- Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease.Environment international · 2018Article
- The Characterization of Polycyclic Aromatic Hydrocarbons in Northeastern US Trucking Terminals.Annals of work exposures and health · 2017Article
- Association between inflammation processes, DNA damage, and exposure to environmental pollutants.Environmental science and pollution research international · 2017Article
- Residential Proximity to Major Roadways and Risk of Type 2 Diabetes Mellitus: A Meta-Analysis.International journal of environmental research and public health · 2016Article
- Addressing Emerging Risks: Scientific and Regulatory Challenges Associated with Environmentally Persistent Free Radicals.International journal of environmental research and public health · 2016Review
- Fine particles, genetic pathways, and markers of inflammation and endothelial dysfunction: Analysis on particulate species and sources.Journal of exposure science & environmental epidemiology · 2016Article
- Fine particulate matter induces vascular endothelial activationToxicology research · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundExperimental evidence suggests that inhaled particles from vehicle exhaust have systemic effects on inflammation, endothelial activation and oxidative stress. In the present study we assess the relationships of short-term exposures with inflammatory endothelial activation and oxidative stress biomarker levels in a population of trucking industry workers.
methodsBlood and urine samples were collected pre and post-shift, at the beginning and end of a workweek from 67 male non-smoking US trucking industry workers. Concurrent measurements of microenvironment concentrations of elemental and organic carbon (EC & OC), and fine particulate matter (PM2.5) combined with time activity patterns allowed for calculation of individual exposures. Associations between daily and first and last-day average levels of exposures and repeated measures of intercellular and vascular cell adhesion molecule-1 (ICAM-1 & VCAM-1), interleukin 6 (IL-6) and C-reactive protein (CRP) blood levels and urinary 8-Hydroxy-2'-Deoxyguanosine (8-OHdG) were assessed using linear mixed effects models for repeated measures.
resultsThere was a statistically significant association between first and last-day average PM2.5 and 8-OHdG (21% increase, 95% CI: 2, 42%) and first and last-day average OC and IL-6 levels (18% increase 95% CI: 1, 37%) per IQR in exposure. There were no significant findings associated with EC or associations suggesting acute cross-shift effects.
conclusionOur findings suggest associations between weekly average exposures of PM2.5 on markers of oxidative stress and OC on IL-6 levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.