ArticleBMC infectious diseases2013
Epidemiological changes in meningococcal meningitis in Niger from 2008 to 2011 and the impact of vaccination.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global, regional, and national burden of meningitis and its aetiologies, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.The Lancet. Neurology · 2023Pooled it
- Range of Clinical Manifestations Caused by Invasive Meningococcal Disease Due to Serogroup W: A Systematic Review.Infectious diseases and therapy · 2023Review
- Exploring the Ability of Meningococcal Vaccines to Elicit Mucosal Immunity: Insights from Humans and Mice.Pathogens (Basel, Switzerland) · 2021Review
- Impact of MenAfriVac on Meningococcal A Meningitis in Cameroon: A Retrospective Study Using Case-by-Case-Based Surveillance Data from 2009 to 2015.Journal of tropical medicine · 2021Article
- Transmissibility and pathogenicity of the emerging meningococcal serogroup W sequence type-11 complex South American strain: a mathematical modeling study.BMC medicine · 2020Article
- Epidemiology of Bacterial Meningitis in the Nine Years Since Meningococcal Serogroup A Conjugate Vaccine Introduction, Niger, 2010-2018.The Journal of infectious diseases · 2019Article
- Cost-Effectiveness of Alternative Uses of Polyvalent Meningococcal Vaccines in Niger: An Agent-Based Transmission Modeling Study.Medical decision making : an international journal of the Society for Medical Decision Making · 2019Article
- Risk factors for acquisition of meningococcal carriage in the African meningitis belt.Tropical medicine & international health : TM & IH · 2019Article
- Environmental, economic and socio-cultural risk factors of recurrent seasonal epidemics of cerebrospinal meningitis in Kebbi state, northwestern Nigeria: a qualitative approach.BMC public health · 2018Article
- Elimination of Epidemic Meningitis in the African Region: Progress and Challenges: 2010-2016.Journal of immunological sciences · 2018Article
- Molecular Characterization of Invasive Isolates of Neisseria meningitidis in Casablanca, Morocco.Journal of clinical microbiology · 2018Article
- Article
- Current perspectives on invasive nontyphoidal Salmonella disease.Current opinion in infectious diseases · 2017Review
- Analysis of novel meningococcal vaccine formulations.Human vaccines & immunotherapeutics · 2017Article
- OUTBREAK OF CEREBROSPINAL MENINGITIS IN KEBBI STATE, NIGERIA.Annals of Ibadan postgraduate medicine · 2017Article
- Emergence and control of epidemic meningococcal meningitis in sub-Saharan Africa.Pathogens and global health · 2017Review
- Of the Phrensy: an update on the epidemiology and pathogenesis of bacterial meningitis in the pediatric population.F1000Research · 2017Review
- Comparison of school based and supplemental vaccination strategies in the delivery of vaccines to 5-19 year olds in Africa - a systematic review.F1000Research · 2017Article
- Emergence of epidemic Neisseria meningitidis serogroup C in Niger, 2015: an analysis of national surveillance data.The Lancet. Infectious diseases · 2016Article
- Whole-Genome Characterization of Epidemic Neisseria meningitidis Serogroup C and Resurgence of Serogroup W, Niger, 2015.Emerging infectious diseases · 2016Article
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Abstract
backgroundThe epidemiology of bacterial meningitis in the African 'meningitis belt' changes periodically. In order to design an effective vaccination strategy, we have examined the epidemiological and microbiological patterns of bacterial meningitis, and especially that of meningococcal meningitis, in Niger during the period 2008-2011. During this period a mass vaccination campaign with the newly developed meningococcal A conjugate vaccine (MenAfriVac®) was undertaken.
methodCerebrospinal fluid samples were collected from health facilities throughout Niger and analysed by culture, seroagglutination and/or speciation polymerase chain reaction, followed by genogrouping PCR for Neisseria meningitidis infections. A sample of strains were analysed by multi-locus sequence typing.
resultsN. meningitidis serogroup A cases were prevalent in 2008 and 2009 [98.6% and 97.5% of all N. meningitidis cases respectively]. The prevalence of serogroup A declined in 2010 [26.4%], with the emergence of serogroup W Sequence Type (ST) 11 [72.2% of cases], and the serogroup A meningococcus finally disappeared in 2011. The geographical distribution of cases N. meningitidis serogroups A and W within Niger is described.
conclusionThe substantial decline of serogroup A cases that has been observed from 2010 onwards in Niger seems to be due to several factors including a major polysaccharide A/C vaccination campaign in 2009, the introduction of MenAfriVac® in 10 districts at risk in December 2010, the natural dynamics of meningococcal infection and the persistence of serogroup A sequence-type 7 for about 10 years. The emergence of serogroup W strains suggests that there may be a need for serogroup W containing vaccines in Niger in the coming years.
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