ArticleHIV medicine2014
Urinary biomarkers of kidney injury are associated with all-cause mortality in the Women's Interagency HIV Study (WIHS).
Article in HIV medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Urinary Biomarkers of Tubular Damage Are Associated with Mortality but Not Cardiovascular Risk among Systolic Blood Pressure Intervention Trial Participants with Chronic Kidney Disease.American journal of nephrology · 2019Trial
- Urine Injury Biomarkers and Risk of Adverse Outcomes in Recipients of Prevalent Kidney Transplants: The Folic Acid for Vascular Outcome Reduction in Transplantation Trial.Journal of the American Society of Nephrology : JASN · 2016Trial
- Urine kidney injury molecule-1 predicts subclinical kidney disease among persons living with HIV initiating tenofovir disoproxil fumarate-based ART in Zambia.Frontiers in nephrology · 2024Article
- Protein Biomarkers in Chronic Kidney Disease in Children-What Do We Know So Far?Journal of clinical medicine · 2023Review
- Selected biochemical parameters in the urine of HIV-infected patients in monitoring of kidney function.Archives of medical science : AMS · 2023Article
- Profiling Biomarkers in HIV Glomerular Disease - Potential for the Non-Invasive Diagnosis of HIVAN?International journal of nephrology and renovascular disease · 2021Article
- The utility of kidney injury molecule-1 as an early biomarker of kidney injury in people living with HIV.International journal of STD & AIDS · 2020Article
- Management of Presumed Acute Kidney Injury during Hypertensive Therapy: Stay Calm and Carry on?American journal of nephrology · 2020Review
- Distinct Dimensions of Kidney Health and Risk of Cardiovascular Disease, Heart Failure, and Mortality.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Kidney disease risk factors associate with urine biomarkers concentrations in HIV-positive persons; a cross-sectional study.BMC nephrology · 2019Article
- Emerging biomarkers of chronic kidney disease in children.Pediatric nephrology (Berlin, Germany) · 2018Review
- The association between urinary liver-type fatty acid-binding protein and chronic kidney disease classification in HIV-infected Japanese patients.Clinical and experimental nephrology · 2017Article
- Kidney Disease in HIV: Moving beyond HIV-Associated Nephropathy.Journal of the American Society of Nephrology : JASN · 2017Review
- Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study.Clinical journal of the American Society of Nephrology : CJASN · 2017Article
- Changes in Urinary Biomarkers Over 10 Years Is Associated With Viral Suppression in a Prospective Cohort of Women Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression.Kidney international · 2017Article
- Association of HIV infection with biomarkers of kidney injury and fibrosis in the Multicenter AIDS Cohort Study.Antiviral therapy · 2017Article
- Use of urine biomarker-derived clusters to predict the risk of chronic kidney disease and all-cause mortality in HIV-infected women.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Article
- Urinary Markers of Tubular Injury in HIV-Infected Patients.Biochemistry research international · 2016Review
- Epidemiology, clinical characteristics, and management of chronic kidney disease in human immunodeficiency virus-infected patients.World journal of nephrology · 2015Review
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Authors and funding
16 authors at 12 institutions in 1 country.
Funding
Abstract
objectivesChronic kidney disease (CKD) is common in HIV-infected individuals, and is associated with mortality in both the HIV-infected and general populations. Urinary markers of tubular injury have been associated with future kidney disease risk, but associations with mortality are unknown.
methodsWe evaluated the associations of urinary interleukin-18 (IL-18), liver fatty acid binding protein (L-FABP), kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL) and the albumin-to-creatinine ratio (ACR) with 10-year, all-cause death in 908 HIV-infected women. Serum cystatin C was used to estimate the glomerular filtration rate (eGFRcys).
resultsThere were 201 deaths during 9269 person-years of follow-up. After demographic adjustment, compared with the lowest tertile, the highest tertiles of IL-18 [hazard ratio (HR) 2.54; 95% confidence interval (CI) 1.75-3.68], KIM-1 (HR 2.04; 95% CI 1.44-2.89), NGAL (HR 1.50; 95% CI 1.05-2.14) and ACR (HR 1.63; 95% CI 1.13-2.36) were associated with higher mortality. After multivariable adjustment including adjustment for eGFRcys, only the highest tertiles of IL-18 (HR 1.88; 95% CI 1.29-2.74) and ACR (HR 1.46; 95% CI 1.01-2.12) remained independently associated with mortality. Findings for KIM-1 were borderline (HR 1.41; 95% CI 0.99-2.02). We found a J-shaped association between L-FABP and mortality. Compared with persons in the lowest tertile, the HR for the middle tertile of L-FABP was 0.67 (95% CI 0.46-0.98) after adjustment. Associations were stronger when IL-18, ACR and L-FABP were simultaneously included in models.
conclusionsAmong HIV-infected women, some urinary markers of tubular injury are associated with mortality risk, independently of eGFRcys and ACR. These markers represent potential tools with which to identify early kidney injury in persons with HIV infection.
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