ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2014
Phenotype and functionality of CD4+ and CD8+ T cells in the upper reproductive tract of healthy premenopausal women.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 40 citations in OpenAlex.
- Initiating Intramuscular Depot Medroxyprogesterone Acetate Increases Frequencies of Th17-like Human Immunodeficiency Virus Target Cells in the Genital Tract of Women in South Africa: A Randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Effects of the levonorgestrel-releasing intrauterine device on the immune microenvironment of the human cervix and endometrium.American journal of reproductive immunology (New York, N.Y. : 1989) · 2016Trial
- Trial
- Genital Tract and Circulating CD8+ T Cell Phenotypes Vary Across the Menstrual Cycle.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- T-Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- The dysregulation of the immune microenvironment during endometrial intraepithelial neoplasia serves as a marker of endometrial carcinogenesis.Frontiers in immunology · 2026Review
- SCM-198 Inhibits EMS Development by Reversing Decreased Proportions of IFN-γReproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Decreased CCL5 expression in endometrial stromal cells induces deficient CCR5Acta biochimica et biophysica Sinica · 2025Article
- Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa.Immunity & ageing : I & A · 2023Article
- Do endometrial immune changes with age prior to menopause compromise fertility in women?Exploration of immunology · 2022Article
- IL-17A reprograms intestinal epithelial cells to facilitate HIV-1 replication and outgrowth in CD4+ T cells.iScience · 2021Article
- Article
- Direct and Indirect endocrine-mediated suppression of human endometrial CD8+T cell cytotoxicity.Scientific reports · 2021Article
- Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women.Frontiers in immunology · 2021Article
- Human Tissue-Resident Memory T Cells in the Maternal-Fetal Interface. Lost Soldiers or Special Forces?Cells · 2020Review
- Parallel studies of mucosal immunity in the reproductive and gastrointestinal mucosa of HIV-infected women.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Article
- The endometrial immune environment of women with endometriosis.Human reproduction update · 2019Review
- Tissue issues: mucosal T-cell responses in HIV-1 infection.Current opinion in HIV and AIDS · 2019Review
- Evaluation of Mucosal Humoral and Cellular Immune Responses to HIV in External Secretions and Mucosal Tissues.Current immunology reviews · 2019Article
- Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond.Current immunology reviews · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
problemThe goal of this study was to investigate the phenotype and functional responsiveness of CD4(+) and CD8(+) T-cells in the upper reproductive tract of healthy premenopausal women. The lower reproductive tract is frequently studied as a site of sexually transmitted infections; however, the upper reproductive tract may also be a portal of entry and dissemination for pathogens, including HIV-1. METHOD OF STUDY: Endometrial biopsy, endocervical curettage, cytobrush, and blood were collected during mid-luteal phase from 23 healthy women. T-cells were isolated and analyzed by flow cytometry.
resultsAs compared with their counterparts in blood, endometrial and endocervical T-cells had enhanced CCR5 expression, and were enriched for activated, effector memory cells. Endometrial T-cells were more responsive to polyclonal stimuli, producing a broad range of cytokines and chemokines.
conclusionThese findings underscore the responsiveness of endometrial T-cells to stimulation, and reveal their activated phenotype. These findings also suggest susceptibility of the upper reproductive tract to HIV-1 infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.