ArticleBMC geriatrics2013
The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training.
Article in BMC geriatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- The frequency of the ACTN3 polymorphism in Brazil: a systematic review and meta-analysis.BMC medical genomics · 2025Pooled it
- Pooled it
- Pooled it
- Comparative Study in Physical Fitness in Recreative Young Padel Players.Journal of functional morphology and kinesiology · 2025Article
- ACTN3 Genotypes and Their Relationship with Muscle Mass and Function of Kosovan Adults.International journal of environmental research and public health · 2021Article
- Responses to Maximal Strength Training in Different Age and Gender Groups.Frontiers in physiology · 2021Article
- Strength and Endurance Training in Older Women in Relation toInternational journal of environmental research and public health · 2020Article
- Distribution of allele frequencies for genes associated with physical activity and/or physical capacity in a homogenous Norwegian cohort- a cross-sectional study.BMC genetics · 2020Article
- Association ofInternational journal of environmental research and public health · 2019Article
- More than a 'speed gene': ACTN3 R577X genotype, trainability, muscle damage, and the risk for injuries.European journal of applied physiology · 2019Review
- The ACTN3 R577X Polymorphism Is Associated with Cardiometabolic Fitness in Healthy Young Adults.PloS one · 2015Article
- Gold(III) macrocycles: nucleotide-specific unconventional catalytic inhibitors of human topoisomerase I.Journal of the American Chemical Society · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe studied the influence of the ACE I/D and ACTN3 R577X polymorphisms (single or combined) on lower-extremity function in older women in response to high-speed power training.
methodsOne hundred and thirty-nine healthy older Caucasian women participated in this study (age: 65.5 ± 8.2 years, body mass: 67.0 ± 10.0 kg and height: 1.57 ± 0.06 m). Walking speed (S10) performance and functional capacity assessed by the "get-up and go" (GUG) mobility test were measured at baseline (T1) and after a consecutive 12-week period of high-speed power training (40-75% of one repetition maximum in arm and leg extensor exercises; 3 sets 4-12 reps, and two power exercises for upper and lower extremity). Genomic DNA was extracted from blood samples, and genotyping analyses were performed by PCR methods. Genotype distributions between groups were compared by Chi-Square test and the gains in physical performance were analyzed by two-way, repeated-measures ANOVA.
resultsThere were no significant differences between genotype groups in men or women for adjusted baseline phenotypes (P > 0.05). ACE I/D and ACTN3 polymorphisms showed a significant interaction genotype-training only in S10 (P = 0.012 and P = 0.044, respectively) and not in the GUG test (P = 0.311 and P = 0.477, respectively). Analyses of the combined effects between genotypes showed no other significant differences in all phenotypes (P < 0.05) at baseline. However, in response to high-speed power training, a significant interaction on walking speed (P = 0.048) was observed between the "power" (ACTN3 RR + RX & ACE DD) versus "non-power" muscularity-oriented genotypes (ACTN3 XX & ACE II + ID)].
conclusionsThus, ACE I/D and ACTN3 R577X polymorphisms are likely candidates in the modulation of exercise-related gait speed phenotype in older women but not a significant influence in mobility traits.
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