Evidence map›Paper›PMID 24313747›Full record

ArticleInorganic chemistry2014

Underscoring the influence of inorganic chemistry on nuclear imaging with radiometals.

Brian M Zeglis, Jacob L Houghton, Michael J Evans, Nerissa Viola-Villegas, Jason S Lewis

Abstract read
In one paragraph

Article in Inorganic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Neuromolecular medicine · 2026
    Article
  2. Article
  3. Article
  4. Scandium-44: Diagnostic Feasibility in Tumor-Related Angiogenesis.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  11. Article
  12. A brief overview of metal complexes as nuclear imaging agents.Dalton transactions (Cambridge, England : 2003) · 2019
    Review
  13. The synthesis of aRSC advances · 2019
    Article
  14. Article
  15. A dual-responsive probe for detecting cellular hypoxia usingChemical communications (Cambridge, England) · 2019
    Article
  16. Tuning the properties of tris(hydroxypyridinone) ligands: efficientDalton transactions (Cambridge, England : 2003) · 2019
    Article
  17. Review
  18. Journal of labelled compounds & radiopharmaceuticals · 2018
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brian M ZeglisDepartment of Radiology and the Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center , New York, New York, United States.
Jacob L Houghton
Michael J Evans
Nerissa Viola-Villegas
Jason S Lewis

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Annotating Oncogene Status in Prostate Cancer with Zr-89-transferrin PETR01CA176671 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI EVANS, MICHAEL JOHN, LEWIS, JASON S. · 2013 to 2017
$3.1M
Biomarkers for predicting response to Hsp90 therapyR01CA172546 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHIOSIS, GABRIELA, DUNPHY, MARK P. · 2013 to 2017
$2.9M
Noninvasive measurement of oncogenic signaling pathways with 89Zr-transferrinR00CA172695 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EVANS, MICHAEL JOHN · 2014 to 2016
$728k
NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA172695NCI NIH HHS R01 CA172546NCI NIH HHS R01 CA176671
6 · The paper itself

Abstract

Over the past several decades, radionuclides have matured from largely esoteric and experimental technologies to indispensible components of medical diagnostics. Driving this transition, in part, have been mutually necessary advances in biomedical engineering, nuclear medicine, and cancer biology. Somewhat unsung has been the seminal role of inorganic chemistry in fostering the development of new radiotracers. In this regard, the purpose of this Forum Article is to more visibly highlight the significant contributions of inorganic chemistry to nuclear imaging by detailing the development of five metal-based imaging agents: (64)Cu-ATSM, (68)Ga-DOTATOC, (89)Zr-transferrin, (99m)Tc-sestamibi, and (99m)Tc-colloids. In a concluding section, several unmet needs both in and out of the laboratory will be discussed to stimulate conversation between inorganic chemists and the imaging community.

Indexed as

AnimalsChelating AgentsChemistry, InorganicDrug Delivery SystemsLigandsMacrocyclic CompoundsMiceMolecular ImagingPositron-Emission TomographyRadiopharmaceuticalsChelating AgentsLigandsMacrocyclic CompoundsRadiopharmaceuticals

Identifiers

PMID24313747
PMCPMC4151561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.