ReviewBiology of the cell2014
Regulation of with-no-lysine kinase signaling by Kelch-like proteins.
Review in Biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Genome-wide identification and expression analysis of the WNK kinase gene family in soybean.Molecular breeding : new strategies in plant improvement · 2024Article
- Genome-Wide Identification and Expression Analysis ofInternational journal of molecular sciences · 2023Article
- Kelch-like protein 3 in human disease and therapy.Molecular biology reports · 2022Review
- CCT and CCT-Like Modular Protein Interaction Domains in WNK Signaling.Molecular pharmacology · 2022Review
- With no lysine kinases: the key regulatory networks and phytohormone cross talk in plant growth, development and stress response.Plant cell reports · 2021Review
- Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.PloS one · 2020Article
- The Molecular Genetics of Gordon Syndrome.Genes · 2019Review
- Article
- Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4.Scientific reports · 2018Article
- Article
- A patient with pseudohypoaldosteronism type II complicated by congenital hypopituitarism carrying aClinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2016Article
- Hypertension: the missing WNKs.American journal of physiology. Renal physiology · 2016Review
- Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.Scientific reports · 2016Article
- Gordon Syndrome: a continuing story.Pediatric nephrology (Berlin, Germany) · 2015Review
- Perspective of future drugs targeting sterile 20/SPS1-related proline/alanine-rich kinase for blood pressure control.World journal of cardiology · 2015Article
- Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3.The Journal of clinical investigation · 2014Article
- WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.Hypertension (Dallas, Tex. : 1979) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2001, with-no-lysine (WNK) kinases were identified as the genes responsible for the human hereditary hypertensive disease pseudohypoaldosteronism type II (PHAII). It took a further 6 years to clarify that WNK kinases participate in a signaling cascade with oxidative stress-responsive gene 1 (OSR1), Ste20-related proline-alanine-rich kinase (SPAK), and thiazide-sensitive NaCl cotransporter (NCC) in the kidney and the constitutive activation of this signaling cascade is the molecular basis of PHAII. Since this discovery, the WNK-OSR1/SPAK-NCC signaling cascade has been shown to be involved not only in PHAII but also in the regulation of blood pressure under normal and pathogenic conditions, such as hyperinsulinemia. However, the molecular mechanisms of WNK kinase regulation by dietary and hormonal factors and by PHAII-causing mutations remain poorly understood. In 2012, two additional genes responsible for PHAII, Kelch-like 3 (KLHL3) and Cullin3, were identified. At the time of their discovery, the molecular mechanisms underlying the interaction between these genes and their involvement in PHAII were unknown. Here we review the pathophysiological roles of the WNK signaling cascade clarified to date and introduce a new mechanism of WNK kinase regulation by KLHL3 and Cullin3, which provides insight on previously unknown mechanisms of WNK kinase regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.