ArticleThe American journal on addictions
Predictive factors for relapse in patients on buprenorphine maintenance.
Article in The American journal on addictions. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Analysis of genetic and clinical factors associated with buprenorphine response.Drug and alcohol dependence · 2021Pooled it
- A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2020Pooled it
- Mindfulness Training vs Recovery Support for Opioid Use, Craving, and Anxiety During Buprenorphine Treatment: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Effects of live-online, group mindfulness training on opioid use and anxiety during buprenorphine treatment: A comparative effectiveness RCT.Contemporary clinical trials · 2024Trial
- Impact of Depressive Symptom Severity on Buprenorphine/Naloxone and Methadone Outcomes in People With Prescription-Type Opioid Use Disorder: Results From a Pragmatic Randomized Controlled Trial.Journal of dual diagnosisTrial
- Article
- Anxiety-like behavior during protracted morphine withdrawal is driven by gut microbial dysbiosis and attenuated with probiotic treatment.Gut microbes · 2025Article
- Low-dose buprenorphine initiation and treatment continuation among hospitalized patients with opioid dependence: A retrospective cohort study.Journal of substance use and addiction treatment · 2024Article
- The Association Between Self-Reported Anxiety and Retention in Opioid Agonist Therapy: Findings From a Canadian Pragmatic Trial.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Article
- Negative Urgency Linked to Craving and Substance Use Among Adults on Buprenorphine or Methadone.The journal of behavioral health services & research · 2024Article
- Effects of a trauma-informed mindful recovery program on comorbid pain, anxiety, and substance use during primary care buprenorphine treatment: A proof-of-concept study.The American journal on addictions · 2023Article
- Prevalence of alcohol consumption among clients of opioid agonist treatment (OAT) centers in Golestan province, Iran.Frontiers in psychiatry · 2023Article
- Buprenorphine treatment episode duration, dosage, and concurrent prescribing of benzodiazepines and opioid analgesics: The effects of Medicaid prior authorization policies.Drug and alcohol dependence · 2022Article
- Preclinical Characterization and Development on NAQ as a Mu Opioid Receptor Partial Agonist for Opioid Use Disorder Treatment.ACS pharmacology & translational science · 2022Article
- Novel digital approaches to the assessment of problematic opioid use.BioData mining · 2022Review
- Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists.Journal of medicinal chemistry · 2022Article
- Latent trajectories of anxiety and depressive symptoms among adults in early treatment for nonmedical opioid use.Journal of affective disorders · 2022Article
- Cannabis use and opioid relapse: An exploratory survival analysis of prospectively collected data.Frontiers in psychiatry · 2022Article
- Nonclinical pharmacology of daridorexant: a new dual orexin receptor antagonist for the treatment of insomnia.Psychopharmacology · 2021Review
- Use of methamphetamine and alcohol among people with opioid use disorder and HIV in Vietnam: a qualitative study.BMC public health · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
BACKGROUND AND
objectivesDespite the dramatic increase in the use of buprenorphine for the treatment of opioid dependence, clinical outcomes of this treatment approach continue to need evaluation. This study examines factors associated with relapse and retention during buprenorphine treatment in a sample of opioid dependent outpatients.
methodsIn a retrospective chart review of 62 patients with opioid dependence, relapse was determined by self-report, urine toxicology screens, and by checking the state controlled substance monitoring database. Data was analyzed using two-way tests of association and logistic regression.
resultsPatients with comorbid anxiety disorders, active benzodiazepine use (contrary to clinic policy), or active alcohol abuse, were significantly more likely to relapse. Patients who relapsed were also more likely to be on a higher buprenorphine maintenance dose.
conclusionThis study identifies relapse risk factors during buprenorphine treatment for opioid dependence. Future research is needed to determine whether modifying these factors may lead to improved treatment outcomes.
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