ArticleMolecular and cellular biology1986
Alternative RNA splicing generates transcripts encoding a thorax-specific isoform of Drosophila melanogaster myosin heavy chain.
Article in Molecular and cellular biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 103 citations in OpenAlex.
- Enhanced expression of the myogenic factor Myocyte enhancer factor-2 in imaginal disc myoblasts activates a partial, but incomplete, muscle development program.Developmental biology · 2024Article
- Genome-Wide Identification and Expression Profiles of Myosin Genes in the Pacific White Shrimp,Frontiers in physiology · 2019Article
- Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Myosin II sequences for Lethocerus indicus.Journal of muscle research and cell motility · 2017Article
- An embryonic myosin isoform enables stretch activation and cyclical power in Drosophila jump muscle.Biophysical journal · 2013Article
- Drosophila models of cardiac disease.Progress in molecular biology and translational science · 2011Review
- Comparative genomic analysis of the arthropod muscle myosin heavy chain genes allows ancestral gene reconstruction and reveals a new type of 'partially' processed pseudogene.BMC molecular biology · 2008Article
- Inferring alternative splicing patterns in mouse from a full-length cDNA library and microarray data.Genome research · 2002Article
- Assembly of thick filaments and myofibrils occurs in the absence of the myosin head.The EMBO journal · 1999Article
- The role of evolutionarily conserved sequences in alternative splicing at the 3' end of Drosophila melanogaster myosin heavy chain RNA.Genetics · 1999Article
- Evolutionary conservation of regulatory strategies for the sex determination factor transformer-2.Molecular and cellular biology · 1997Article
- Drosophila paramyosin/miniparamyosin gene products show a large diversity in quantity, localization, and isoform pattern: a possible role in muscle maturation and function.The Journal of cell biology · 1996Article
- Transformation of Drosophila melanogaster with the wild-type myosin heavy-chain gene: rescue of mutant phenotypes and analysis of defects caused by overexpression.The Journal of cell biology · 1994Article
- Article
- A non-flight muscle isoform of Drosophila tropomyosin rescues an indirect flight muscle tropomyosin mutant.Journal of muscle research and cell motility · 1993Article
- An unconventional myosin heavy chain gene from Drosophila melanogaster.The Journal of cell biology · 1992Article
- Splicing signals in Drosophila: intron size, information content, and consensus sequences.Nucleic acids research · 1992Article
- Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro.Molecular and cellular biology · 1992Article
- Analysis of Drosophila paramyosin: identification of a novel isoform which is restricted to a subset of adult muscles.The Journal of cell biology · 1992Article
- Polypeptide components of Drosophila small nuclear ribonucleoprotein particles.Nucleic acids research · 1991Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Genomic and cDNA sequencing studies show that transcripts from the muscle myosin heavy-chain (MHC) gene of Drosophila melanogaster are alternatively spliced, producing RNAs that encode at least two MHC isoforms with different C termini. Transcripts encoding an MHC isoform with 27 unique C-terminal amino acids accumulate during both larval and adult muscle differentiation. Transcripts for the second isoform encode one unique C-terminal amino acid and accumulate almost exclusively in pupal and adult thoracic segments, the location of the indirect flight muscles. The 3' splice acceptor site preceding the thorax-specific exon is unusually purine rich and thus may serve as a thorax-specific splicing signal. We suggest that the alternative C termini of these two MHC isoforms control myofilament assembly and may play a role in generating the distinctive myofilament organizations of flight muscle and other muscle types.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.