ArticleMedChemComm2011
Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity.
Article in MedChemComm, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Nucleoside Analogs with Fleximer Nucleobase.Chemistry of heterocyclic compounds · 2020Article
- Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity.Molecules (Basel, Switzerland) · 2019Article
- Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1.Bioorganic & medicinal chemistry · 2019Article
- Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation.Beilstein journal of organic chemistry · 2016Article
- Design and synthesis of a series of truncated neplanocin fleximers.Molecules (Basel, Switzerland) · 2014Article
- Syntheses of isoxazoline-carbocyclic nucleosides and their antiviral evaluation: a standard protocol.TheScientificWorldJournal · 2014Article
- "Reverse" carbocyclic fleximers: synthesis of a new class of adenosine deaminase inhibitors.Nucleosides, nucleotides & nucleic acids · 2013Article
- Flexibility-Not just for yoga anymore!Antiviral chemistry & chemotherapyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
A series of 5'-nor carbocyclic "reverse" flexible nucleosides or "fleximers" have been designed wherein the nucleobase scaffold resembles a "split" purine as well as a substituted pyrimidine. This modification was employed to explore recognition by both purine and pyrimidine metabolizing enzymes. The synthesis of the carbocyclic fleximers and the results of their preliminary biological screening are described herein.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.