ArticleGut and liver2013
Seasonal variation in months of birth and symptom flares in Korean patients with inflammatory bowel disease.
Article in Gut and liver, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Pooled it
- Evolution of inflammatory bowel disease in Korea: a 60-year perspective on clinical and research development.Intestinal research · 2025Review
- Changes in clinical features and seasonal variations of Crohn's disease at diagnosis: a 10-year observational study in China.Frontiers in medicine · 2024Article
- Article
- Seasonal Variation of Antiretroviral Drug Exposure during the Year: The Experience of 10 Years of Therapeutic Drug Monitoring.Biomedicines · 2021Article
- Article
- The Impact of Cold Spells on the Incidence of Infectious Gastroenteritis and Relapse Rates of Inflammatory Bowel Disease: A Retrospective Controlled Observational Study.Inflammatory intestinal diseases · 2017Article
- Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease.Journal of gastroenterology · 2017Observational
- Disease Phenotype, Activity and Clinical Course Prediction Based on C-Reactive Protein Levels at Diagnosis in Patients with Crohn's Disease: Results from the CONNECT Study.Gut and liver · 2016Article
- Characteristics of Pediatric Inflammatory Bowel Disease in Korea: Comparison with EUROKIDS Data.Gut and liver · 2015Article
- Seasonal Variation in Flares of Intestinal Behçet's Disease.Digestive diseases and sciences · 2015Article
- Does the Cyclosporine Still Have a Potential Role in the Treatment of Acute Severe Steroid-Refractory Ulcerative Colitis?Gut and liver · 2015Article
- Inflammatory Bowel Disease Cohort Studies in Korea: Present and Future.Intestinal research · 2015Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsSeasonal variation may influence the development and exacerbation of inflammatory bowel disease (IBD). However, most epidemiologic studies on this topic have been conducted in Western countries. The purpose of this study was to determine whether birth dates and symptom flares follow a seasonal pattern in Korean patients with IBD.
methodsPatients with a diagnosis of IBD established between January 2003 and December 2010 were investigated at six university hospitals in Korea. The expected births and flares, with a uniform distribution during the year and considering differences in the number of days in the months of 1 year, were calculated.
resultsA total of 411 patients with ulcerative colitis (UC) and 316 patients with Crohn disease (CD) were included in the study. Birth during the winter period, and especially in January and February, was associated with an increased risk of IBD, especially in UC patients. The symptom flares of CD patients occurred most frequently in the spring, with a nadir in the autumn. However, no disease flare seasonality was noted for UC patients.
conclusionsOur data suggest that seasonally varying environmental factors during pregnancy and the postpartum period are associated with a susceptibility to IBD later in life and that exacerbations of CD are influenced by seasonal factors.
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