ArticleMolecular and cellular biology1986
Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes.
Article in Molecular and cellular biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 75 citations in OpenAlex.
- Differential expression of cytokeratin mRNA and protein in normal prostate, prostatic intraepithelial neoplasia, and invasive carcinoma.The American journal of pathology · 1997Article
- Mutation of human keratin 18 in association with cryptogenic cirrhosis.The Journal of clinical investigation · 1997Article
- Intermediate filament expression in prostate cancer.Cancer metastasis reviews · 1996Review
- A review of intermediate filament biology and their use in pathologic diagnosis.Molecular biology reports · 1994Review
- An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns.The Journal of cell biology · 1990Article
- Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control.Molecular and cellular biology · 1989Article
- Two type II keratin genes are localized on human chromosome 12.Human genetics · 1989Article
- Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation.The Journal of cell biology · 1988Article
- Localization of keratin mRNA in human tracheobronchial epithelium and bronchogenic carcinomas by in situ hybridization.The American journal of pathology · 1988Article
- Molecular characterization and expression of the stratification-related cytokeratins 4 and 15.The Journal of cell biology · 1988Article
- Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells.Molecular and cellular biology · 1988Article
- A group of type I keratin genes on human chromosome 17: characterization and expression.Molecular and cellular biology · 1988Article
- Sequence of the human 40-kDa keratin reveals an unusual structure with very high sequence identity to the corresponding bovine keratin.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Sequence and expression of a type II keratin, K5, in human epidermal cells.Molecular and cellular biology · 1988Article
- Concerted gene duplications in the two keratin gene families.Journal of molecular evolution · 1988Article
- Sequence of cDNA coding for human keratin 19.Nucleic acids research · 1987Article
- Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes.Nucleic acids research · 1987Article
- The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.The EMBO journal · 1987Article
- Differentially expressed bovine cytokeratin genes. Analysis of gene linkage and evolutionary conservation of 5'-upstream sequences.The EMBO journal · 1987Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
We have isolated and subcloned three separate segments of human DNA which share strong sequence homology with a previously sequenced gene encoding a type I keratin, K14 (50 kilodaltons). Restriction endonuclease mapping has demonstrated that these three genes are tightly linked chromosomally, whereas the K14 gene appears to be separate. As judged by positive hybridization-translation and Northern blot analyses, the central linked gene encodes a keratin, K17, which is expressed in abundance with K14 and two other type I keratins in cultured human epidermal cells. None of these other epidermal keratin mRNAs appears to be generated from the K17 gene through differential splicing of its transcript. The sequence of the K17 gene reveals striking homologies not only with the coding portions and intron positions of the K14 gene, but also with its 5'-noncoding and 5'-upstream sequences. These similarities may provide an important clue in elucidating the molecular mechanisms underlying the coexpression of the two genes.
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