Trial reportPloS one2013
Is there an association between work stress and diurnal cortisol patterns? Findings from the Whitehall II study.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Psychosocial functioning and the cortisol awakening response: Meta-analysis, P-curve analysis, and evaluation of the evidential value in existing studies.Biological psychology · 2017Pooled it
- Effort-Reward Imbalance at Work and Incident Coronary Heart Disease: A Multicohort Study of 90,164 Individuals.Epidemiology (Cambridge, Mass.) · 2017Pooled it
- A Narrative Review of AI Frameworks for Chronic Stress Detection Using Physiological Sensing: Resting, Longitudinal, and Reactivity Perspectives.Sensors (Basel, Switzerland) · 2026Review
- Diurnal pattern of salivary cortisol and progression of aortic stiffness: Longitudinal study.Psychoneuroendocrinology · 2021Article
- Perceived stress is linked to heightened biomarkers of inflammation via diurnal cortisol in a national sample of adults.Brain, behavior, and immunity · 2021Article
- Dopamine Receptor D2 Gene (DRD2) Polymorphisms, Job Stress, and Their Interaction on Sleep Dysfunction.International journal of environmental research and public health · 2020Article
- The Influence of Negative Mental Health on the Health Behavior and the Mortality Risk: Analysis of Korean Longitudinal Study of Aging from 2006 to 2014.Korean journal of family medicine · 2019Article
- Association of glucocorticoid receptor gene polymorphism and occupational stress with hypertension in desert petroleum workers in Xinjiang, China.BMC medical genetics · 2018Article
- Retirement and Socioeconomic Differences in Diurnal Cortisol: Longitudinal Evidence From a Cohort of British Civil Servants.The journals of gerontology. Series B, Psychological sciences and social sciences · 2018Article
- The effects of a workplace intervention on employees' cortisol awakening response.Community, work & family · 2018Article
- Work Stress and Altered Biomarkers: A Synthesis of Findings Based on the Effort-Reward Imbalance Model.International journal of environmental research and public health · 2017Review
- Relationship between psychosocial stress dimensions and salivary cortisol in military police officers.Revista latino-americana de enfermagem · 2017Article
- Biopsychosocial pathways linking subjective socioeconomic disadvantage to glycemic control in youths with type I diabetes.Psychoneuroendocrinology · 2017Article
- Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus.Annals of the New York Academy of Sciences · 2017Review
- Multiple Imputation When Rate of Change is the Outcome of Interest.Journal of modern applied statistical methods : JMASM · 2016Article
- Job Strain and the Cortisol Diurnal Cycle in MESA: Accounting for Between- and Within-Day Variability.American journal of epidemiology · 2016Article
- Psychological job strain, social support at work and daytime secretion of dehydroepiandrosterone (DHEA) in healthy female employees: cross-sectional analyses.Scientific reports · 2015Article
- Is musculoskeletal pain a consequence or a cause of occupational stress? A longitudinal study.International archives of occupational and environmental health · 2015Article
- The effort-reward imbalance work-stress model and daytime salivary cortisol and dehydroepiandrosterone (DHEA) among Japanese women.Scientific reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe evidence on whether there is work stress related dysregulation of the hypothalamic-pituitary-adrenal axis is equivocal. This study assessed the relation between work stress and diurnal cortisol rhythm in a large-scale occupational cohort, the Whitehall II study.
methodsWork stress was assessed in two ways, using the job-demand-control (JDC) and the effort-reward-imbalance (ERI) models. Salivary cortisol samples were collected six times over a normal day in 2002-2004. The cortisol awakening response (CAR) and diurnal cortisol decline (slope) were calculated.
resultsIn this large occupational cohort (N = 2,126, mean age 57.1), modest differences in cortisol patterns were found for ERI models only, showing lower reward (β = -0.001, P-value = 0.04) and higher ERI (β = 0.002, P-value = 0.05) were related to a flatter slope in cortisol across the day. Meanwhile, moderate gender interactions were observed regarding CAR and JDC model.
conclusionsWe conclude that the associations of work stress with cortisol are modest, with associations apparent for ERI model rather than JDC model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.