Trial reportPloS one2013
Transorbital sonographic evaluation of normal optic nerve sheath diameter in healthy volunteers in Bangladesh.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 99 citations in OpenAlex.
- Correlation of optic nerve sheath diameter with directly measured intracranial pressure in Korean adults using bedside ultrasonography.PloS one · 2017Trial
- Impact of controlled intraabdominal pressure on the optic nerve sheath diameter during laparoscopic procedures.Surgical endoscopy · 2016Trial
- The effects of positive end-expiratory pressure (PEEP) application on optic nerve sheath diameter in patients undergoing laparoscopic cholecystectomy: a randomized trial.Brazilian journal of anesthesiology (Elsevier)Trial
- Optic Nerve Sheath Diameter and Transcranial Doppler Pulsatility Index for Non-Invasive ICP Assessment in Acute Intracerebral Hemorrhage.Brain sciences · 2026Article
- Ultrasonographic optic nerve sheath diameter for predicting elevated intracranial pressure and clinical severity in children: a prospective observational study.European journal of pediatrics · 2026Observational
- Point-of-care ultrasonography for detecting raised intracranial pressure through optic nerve sheath diameter in non-traumatic headache patients.World journal of radiology · 2025Review
- Optic nerve sheath diameter measurement in healthy South Iranian adults from a cross-sectional ultrasonographic study.Scientific reports · 2025Article
- The predictive value of optic nerve sheath diameter measurement via ultrasound for intracerebral hemorrhage complicated by cerebral-cardiac syndrome.BMC neurology · 2025Article
- Prediction of Intracranial Pressure in Patients with an Aneurysmal Subarachnoid Hemorrhage Using Optic Nerve Sheath Diameter via Explainable Predictive Modeling.Journal of clinical medicine · 2024Article
- Non-invasive assessment of intracranial pressure through the eyes: current developments, limitations, and future directions.Frontiers in neurology · 2024Review
- Optic Nerve Sheath Diameter: A Cross-Sectional Study of Ultrasonographic Measurement in Healthy Black South African Adults.Life (Basel, Switzerland) · 2023Article
- Extracorporeal Circulation and Optic Nerve Ultrasound: A Pilot Study.Medicina (Kaunas, Lithuania) · 2023Article
- Optic Nerve Ultrasound Evaluation in Children: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Ultrasound measurement of optic nerve sheath diameter in a healthy adult Colombian population.BMC neurology · 2023Article
- Ultrasonic optic disc height combined with the optic nerve sheath diameter as a promising non-invasive marker of elevated intracranial pressure.Frontiers in physiology · 2023Article
- Optic nerve sheath diameter at high altitude: standardized measures in healthy volunteers.The ultrasound journal · 2022Article
- Optic Nerve Sheath Diameter Ultrasound: A Non-Invasive Approach to Evaluate Increased Intracranial Pressure in Critically Ill Pediatric Patients.Diagnostics (Basel, Switzerland) · 2022Review
- Optic Nerve Sheath Diameter for Predicting Outcomes in Post-Cardiac Arrest Syndrome: An Updated Systematic Review and Meta-Analysis.Journal of personalized medicine · 2022Review
- Optic Nerve Sheath Ultrasound for the Detection and Monitoring of Raised Intracranial Pressure in Tuberculous Meningitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Predictive Utility of Changes in Optic Nerve Sheath Diameter after Cardiac Arrest for Neurologic Outcomes.International journal of environmental research and public health · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
introductionMeasurement of optic nerve sheath diameter (ONSD) by ultrasound is increasingly used as a marker to detect raised intracranial pressure (ICP). ONSD varies with age and there is no clear consensus between studies for an upper limit of normal. Knowledge of normal ONSD in a healthy population is essential to interpret this measurement.
methodsIn a prospective observational study, ONSD was measured using a 15 MHz ultrasound probe in healthy volunteers in Chittagong, Bangladesh. The aims were to determine the normal range of ONSD in healthy Bangladeshi adults and children, compare measurements in males and females, horizontal and vertical beam orientations and left and right eyes in the same individual and to determine whether ONSD varies with head circumference independent of age.
results136 subjects were enrolled, 12.5% of whom were age 16 or under. Median ONSD was 4.41 mm with 95% of subjects in the range 4.25-4.75 mm. ONSD was bimodally distributed. There was no relationship between ONSD and age (≥4 years), gender, head circumference, and no difference in left vs right eye or horizontal vs vertical beam.
conclusionsUltrasonographic ONSD in Bangladeshi healthy volunteers has a narrow bimodal distribution independent of age (≥4 years), gender and head circumference. ONSD >4.75 mm in this population should be considered abnormal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.