ArticlePloS one2013
Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- An integratediScience · 2026Article
- Light at night negatively affects mood in diurnal primate-like tree shrews via a visual pathway related to the perihabenular nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Recognising depression in non-human primates: a narrative review of reported signs of depression.PeerJ · 2025Review
- Animal models of Alzheimer's disease: Current strategies and new directions.Zoological research · 2024Review
- Depicting Primate-Like Granular Dorsolateral Prefrontal Cortex in the Chinese Tree Shrew.eNeuro · 2024Article
- Enhanced long-term potentiation in the anterior cingulate cortex of tree shrew.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Article
- Alterations of Dopamine Receptors and the Adaptive Changes of L-Type Calcium Channel Subtypes Regulate Cocaine-Seeking Habit in Tree Shrew.Life (Basel, Switzerland) · 2022Article
- Characteristics of Angiotensin I-converting enzyme 2, type II transmembrane serine protease 2 and 4 in tree shrew indicate it as a potential animal model for SARS-CoV-2 infection.Bioengineered · 2021Article
- Stress, Subordination, and Anomalies of Feeding Across the Tree of Life: Implications for Interpreting Human Eating Disorders.Frontiers in psychology · 2021Article
- Washed Microbiota Transplantation Accelerates the Recovery of Abnormal Changes by Light-Induced Stress in Tree Shrews.Frontiers in cellular and infection microbiology · 2021Article
- Social avoidance behavior in male tree shrews and prosocial behavior in male mice toward unfamiliar conspecifics in the laboratory.Zoological research · 2020Article
- Establishment of Neurobehavioral Assessment System in Tree Shrew SCT Model.Journal of molecular neuroscience : MN · 2020Article
- Donepezil improves the cognitive impairment in a tree shrew model of Alzheimer's disease induced by amyloid-βMetabolic brain disease · 2018Article
- Atlas of the Striatum and Globus Pallidus in the Tree Shrew: Comparison with Rat and Mouse.Neuroscience bulletin · 2018Article
- Comparison of the properties of neural stem cells of the hippocampus in the tree shrew and rat in vitro.Molecular medicine reports · 2018Article
- Establishment of basal cell carcinoma animal model in Chinese tree shrew (Zoological research · 2017Article
- Tree shrew (Zoological research · 2017Review
- Chronic psychosocial stressors in adulthood: Studies in mice, rats and tree shrews.Neurobiology of stress · 2017Review
- Indomethacin counteracts the effects of chronic social defeat stress on emotional but not recognition memory in mice.PloS one · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic stress is the major cause of clinical depression. The behavioral signs of depression, including anhedonia, learning and memory deficits, and sleep disruption, result from the damaging effects of stress hormones on specific neural pathways. The Chinese tree shrew (Tupaia belangeri chinensis) is an aggressive non-human primate with a hierarchical social structure that has become a well-established model of the behavioral, endocrine, and neurobiological changes associated with stress-induced depression. The tricyclic antidepressant clomipramine treats many of the core symptoms of depression in humans. To further test the validity of the tree shrew model of depression, we examined the effects of clomipramine on depression-like behaviors and physiological stress responses induced by social defeat in subordinate tree shrews. Social defeat led to weight loss, anhedonia (as measured by sucrose preference), unstable fluctuations in locomotor activity, sustained urinary cortisol elevation, irregular cortisol rhythms, and deficient hippocampal long-term potentiation (LTP). Clomipramine ameliorated anhedonia and irregular locomotor activity, and partially rescued the irregular cortisol rhythm. In contrast, weight loss increased, cortisol levels were even higher, and in vitro LTP was still impaired in the clomipramine treatment group. These results demonstrate the unique advantage of the tree shrew social defeat model of depression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.