Trial reportPloS one2013
Reversal of ophthalmic artery flow and stroke outcomes in Asian patients with acute ischemic stroke and unilateral severe cervical carotid stenosis.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Same lesion, different outcomes: hemodynamic correlates of ischemic stroke in unilateral high-grade internal carotid artery stenosis or occlusion - a retrospective transcranial Doppler study.Frontiers in neurology · 2026Article
- [Role of duplex ultrasonography of the ophthalmic artery in internal carotid artery stenosis].Radiologie (Heidelberg, Germany) · 2024Article
- Article
- Measurement of Retrobulbar Blood Flow and Vascular Reactivity-Relevance for Ocular and Cardiovascular Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Impact of cerebral collateral flow on stroke outcomes after carotid stenting.Annals of clinical and translational neurology · 2023Article
- Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion.Neurophotonics · 2023Article
- Ophthalmic artery flow direction change predicts recurrence of ischemic stroke after carotid stenting: a longitudinal observational study.European journal of medical research · 2023Observational
- The age factor influencing long-term physical functionality in stroke patients undergoing intra-arterial thrombectomy treatment.Medicine · 2022Article
- Associations between migraine occurrence and the effect of aura, age at onset, family history, and sex: A cross-sectional study.PloS one · 2020Article
- Association between fasting Triglyceride levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis in a Chinese Community-based Study.Scientific reports · 2018Article
- Decreased Estimated Glomerular Filtration Rate (eGFR), Not Proteinuria, Is Associated with Asymptomatic Intracranial Arterial Stenosis in Chinese General Population.Scientific reports · 2017Article
- Observational
- Collateral Assessment by CT Angiography as a Predictor of Outcome in Symptomatic Cervical Internal Carotid Artery Occlusion.AJNR. American journal of neuroradiology · 2017Article
- First-ever ischemic stroke in elderly patients: predictors of functional outcome following carotid artery stenting.Clinical interventions in aging · 2016Article
- Risk Factor Stratification for Intracranial Stenosis in Taiwanese Patients With Cervicocerebral Stenosis.Journal of the American Heart Association · 2015Article
- Hemorheology and Inflammatory Marker Changes in Patients with Acute Ischemic Stroke after Intravenous Thrombolysis with Mechanical Thrombectomy.Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to assess the clinical implications of reversed ophthalmic artery flow (ROAF) for stroke risk and outcomes in subjects with unilateral severe cervical carotid stenosis/occlusion.
methodsWe investigated 128 subjects (101 with acute stroke and 27 without), selected from a large hospital patients base (n = 14,701), identified with unilateral high-grade cervical carotid stenosis/occlusion by using duplex ultrasonography and brain magnetic resonance imaging. All clinical characteristics were compared for stroke risk between acute stroke and nonstroke groups. Patients with acute stroke were divided into 4 subgroups according to ophthalmic artery flow direction and intracranial stenosis severity, and stroke outcomes were evaluated.
resultsThe acute stroke group had significantly higher percentages of ROAF (52.5%, p = 0.003), carotid occlusion (33.7%, p = 0.046), and severe intracranial stenosis (74.3%, p<0.001). However, multivariate analysis demonstrated that intracranial stenosis was the only significant risk factor (odds ratio = 10.38; 95% confidence interval = 3.64-29.65; p<0.001). Analysis of functional outcomes among the 4 subgroups of patients with stroke showed significant trends (p = 0.018 to 0.001) for better stroke outcomes from ROAF and mild or no intracranial stenosis. ROAF improved 10-20% stroke outcomes, as compared to forward ophthalmic artery flow, among the patients with stroke and the same degree of severities of intracranial stenosis.
conclusionsPatients with acute stroke and severe unilateral cervical carotid stenosis/occlusion significantly have high incidence of intracranial stenosis and ROAF. Intracranial stenosis is a major stroke risk indicator as well as a predictor for worse stroke outcomes, and ROAF may provide partial compensation for improving stroke outcomes.
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